12 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HBQ1	Hemoglobin subunit theta 1. (142 aa)
	ENSP00000496470	GLOBIN domain-containing protein; Belongs to the globin family. (168 aa)
	HBD	Hemoglobin subunit delta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (147 aa)
	NGB	Neuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti- apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. (151 aa)
	HBB	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family. (147 aa)
	CYGB	Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. (190 aa)
	HBE1	Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin; Belongs to the globin family. (147 aa)
	HBZ	Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin. (142 aa)
	HBG2	Hemoglobin subunit gamma-2; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains. (147 aa)
	HBM	Hemoglobin subunit mu. (141 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	HBA2	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues. (142 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYGB	MB	ENSP00000293230	ENSP00000352835	Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.469
CYGB	NGB	ENSP00000293230	ENSP00000298352	Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.	Neuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti- apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.	0.975
ENSP00000496470	HBA2	ENSP00000496470	ENSP00000251595	GLOBIN domain-containing protein; Belongs to the globin family.	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	0.601
ENSP00000496470	HBE1	ENSP00000496470	ENSP00000292896	GLOBIN domain-containing protein; Belongs to the globin family.	Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin; Belongs to the globin family.	0.594
ENSP00000496470	HBM	ENSP00000496470	ENSP00000349270	GLOBIN domain-containing protein; Belongs to the globin family.	Hemoglobin subunit mu.	0.571
ENSP00000496470	HBQ1	ENSP00000496470	ENSP00000199708	GLOBIN domain-containing protein; Belongs to the globin family.	Hemoglobin subunit theta 1.	0.585
ENSP00000496470	HBZ	ENSP00000496470	ENSP00000252951	GLOBIN domain-containing protein; Belongs to the globin family.	Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.	0.590
HBA2	ENSP00000496470	ENSP00000251595	ENSP00000496470	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	GLOBIN domain-containing protein; Belongs to the globin family.	0.601
HBA2	HBB	ENSP00000251595	ENSP00000494175	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	0.999
HBA2	HBD	ENSP00000251595	ENSP00000494708	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemoglobin subunit delta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.	0.997
HBA2	HBE1	ENSP00000251595	ENSP00000292896	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin; Belongs to the globin family.	0.996
HBA2	HBG2	ENSP00000251595	ENSP00000338082	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemoglobin subunit gamma-2; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.	0.994
HBA2	HBM	ENSP00000251595	ENSP00000349270	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemoglobin subunit mu.	0.633
HBA2	HBQ1	ENSP00000251595	ENSP00000199708	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemoglobin subunit theta 1.	0.828
HBA2	HBZ	ENSP00000251595	ENSP00000252951	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.	0.698
HBA2	NGB	ENSP00000251595	ENSP00000298352	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Neuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti- apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis.	0.408
HBB	HBA2	ENSP00000494175	ENSP00000251595	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	0.999
HBB	HBD	ENSP00000494175	ENSP00000494708	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	Hemoglobin subunit delta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family.	0.912
HBB	HBE1	ENSP00000494175	ENSP00000292896	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin; Belongs to the globin family.	0.760
HBB	HBG2	ENSP00000494175	ENSP00000338082	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	Hemoglobin subunit gamma-2; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.	0.862