STRINGSTRING
TSPAN2 TSPAN2 TSPAN9 TSPAN9 TSPAN12 TSPAN12 CD82 CD82 CD81 CD81 TSPAN3 TSPAN3 TSPAN5 TSPAN5 TSPAN17 TSPAN17 CD151 CD151 CD37 CD37 TSPAN1 TSPAN1 TSPAN14 TSPAN14 TSPAN6 TSPAN6 TSPAN7 TSPAN7 CD9 CD9 TSPAN8 TSPAN8 TSPAN4 TSPAN4 B4E171_HUMAN B4E171_HUMAN TSPAN18 TSPAN18 CD63 CD63 TSPAN10 TSPAN10 CD53 CD53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSPAN2Tetraspanin-2; May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath; Belongs to the tetraspanin (TM4SF) family. (221 aa)
TSPAN9Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family. (239 aa)
TSPAN12Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also [...] (305 aa)
CD82CD82 antigen; Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway; Belongs to the tetraspanin (TM4SF) family. (267 aa)
CD81CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] (236 aa)
TSPAN3Tetraspanin-3; Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair; Belongs to the tetraspanin (TM4SF) family. (253 aa)
TSPAN5Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44. Belongs to the tetraspanin (TM4SF) family. (268 aa)
TSPAN17Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family. (332 aa)
CD151CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney. (253 aa)
CD37Leukocyte antigen CD37; CD37 molecule. (281 aa)
TSPAN1Tetraspanin-1; Tetraspanin 1. (241 aa)
TSPAN14Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). (270 aa)
TSPAN6Tetraspanin-6; Tetraspanin 6. (245 aa)
TSPAN7Tetraspanin-7; May be involved in cell proliferation and cell motility. (249 aa)
CD9CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents mac [...] (228 aa)
TSPAN8Tetraspanin-8; Tetraspanin 8. (237 aa)
TSPAN4Tetraspanin-4; Tetraspanin 4; Belongs to the tetraspanin (TM4SF) family. (238 aa)
B4E171_HUMANTetraspanin. (279 aa)
TSPAN18Tetraspanin-18; Tetraspanin 18. (248 aa)
CD63CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] (238 aa)
TSPAN10Tetraspanin-10; Regulates maturation of the transmembrane metalloprotease ADAM10; Belongs to the tetraspanin (TM4SF) family. (393 aa)
CD53Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity). (219 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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