Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IL10 | IL19 | ENSP00000412237 | ENSP00000499459 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines i [...] | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | 0.872 |
| IL10 | IL22 | ENSP00000412237 | ENSP00000442424 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines i [...] | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo. | 0.944 |
| IL10 | IL24 | ENSP00000412237 | ENSP00000375795 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines i [...] | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family. | 0.856 |
| IL19 | IL10 | ENSP00000499459 | ENSP00000412237 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines i [...] | 0.872 |
| IL19 | IL20 | ENSP00000499459 | ENSP00000356065 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | Interleukin-20; Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. | 0.919 |
| IL19 | IL22 | ENSP00000499459 | ENSP00000442424 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo. | 0.830 |
| IL19 | IL24 | ENSP00000499459 | ENSP00000375795 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family. | 0.970 |
| IL19 | IL26 | ENSP00000499459 | ENSP00000229134 | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | Interleukin-26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. | 0.897 |
| IL20 | IL19 | ENSP00000356065 | ENSP00000499459 | Interleukin-20; Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | 0.919 |
| IL20 | IL24 | ENSP00000356065 | ENSP00000375795 | Interleukin-20; Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family. | 0.932 |
| IL22 | IL10 | ENSP00000442424 | ENSP00000412237 | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines i [...] | 0.944 |
| IL22 | IL19 | ENSP00000442424 | ENSP00000499459 | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo. | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | 0.830 |
| IL22 | IL24 | ENSP00000442424 | ENSP00000375795 | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo. | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family. | 0.855 |
| IL22 | IL26 | ENSP00000442424 | ENSP00000229134 | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo. | Interleukin-26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. | 0.883 |
| IL24 | IL10 | ENSP00000375795 | ENSP00000412237 | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family. | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro- inflammatory cytokines i [...] | 0.856 |
| IL24 | IL19 | ENSP00000375795 | ENSP00000499459 | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family. | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | 0.970 |
| IL24 | IL20 | ENSP00000375795 | ENSP00000356065 | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family. | Interleukin-20; Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. | 0.932 |
| IL24 | IL22 | ENSP00000375795 | ENSP00000442424 | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family. | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo. | 0.855 |
| IL24 | IL26 | ENSP00000375795 | ENSP00000229134 | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family. | Interleukin-26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. | 0.827 |
| IL26 | IL19 | ENSP00000229134 | ENSP00000499459 | Interleukin-26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. | Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). | 0.897 |
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