(7 nodes) Methyltransferase domain network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	METTL24	Methyltransferase-like protein 24; Methyltransferase like 24. (366 aa)
	RRNAD1	Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family. (475 aa)
	METTL25	Methyltransferase-like protein 25; Putative methyltransferase. (603 aa)
	EEF1AKMT2	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (291 aa)
	AS3MT	Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. (375 aa)
	MEPCE	7SK snRNA methylphosphate capping enzyme; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it. (689 aa)
	GSTCD	Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family. (633 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEF1AKMT2	METTL24	ENSP00000357829	ENSP00000344071	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	Methyltransferase-like protein 24; Methyltransferase like 24.	0.598
EEF1AKMT2	METTL25	ENSP00000357829	ENSP00000248306	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	Methyltransferase-like protein 25; Putative methyltransferase.	0.800
EEF1AKMT2	RRNAD1	ENSP00000357829	ENSP00000357199	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family.	0.426
METTL24	EEF1AKMT2	ENSP00000344071	ENSP00000357829	Methyltransferase-like protein 24; Methyltransferase like 24.	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	0.598
METTL24	METTL25	ENSP00000344071	ENSP00000248306	Methyltransferase-like protein 24; Methyltransferase like 24.	Methyltransferase-like protein 25; Putative methyltransferase.	0.556
METTL25	EEF1AKMT2	ENSP00000248306	ENSP00000357829	Methyltransferase-like protein 25; Putative methyltransferase.	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	0.800
METTL25	METTL24	ENSP00000248306	ENSP00000344071	Methyltransferase-like protein 25; Putative methyltransferase.	Methyltransferase-like protein 24; Methyltransferase like 24.	0.556
RRNAD1	EEF1AKMT2	ENSP00000357199	ENSP00000357829	Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family.	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	0.426