| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CRNN | FLG | ENSP00000271835 | ENSP00000357789 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | 0.591 |
| CRNN | RPTN | ENSP00000271835 | ENSP00000317895 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. | 0.591 |
| CRNN | TCHH | ENSP00000271835 | ENSP00000480484 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. | 0.417 |
| CRNN | TCHHL1 | ENSP00000271835 | ENSP00000357796 | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | Trichohyalin-like protein 1; Trichohyalin like 1; Belongs to the S-100 family. | 0.601 |
| FLG | CRNN | ENSP00000357789 | ENSP00000271835 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Cornulin; Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways ; Belongs to the S100-fused protein family. | 0.591 |
| FLG | FLG2 | ENSP00000357789 | ENSP00000373370 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | 0.832 |
| FLG | HRNR | ENSP00000357789 | ENSP00000357791 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | 0.603 |
| FLG | RPTN | ENSP00000357789 | ENSP00000317895 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. | 0.799 |
| FLG | S100A7 | ENSP00000357789 | ENSP00000357711 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | S100 calcium binding protein A7. | 0.595 |
| FLG | TCHH | ENSP00000357789 | ENSP00000480484 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. | 0.831 |
| FLG | TCHHL1 | ENSP00000357789 | ENSP00000357796 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | Trichohyalin-like protein 1; Trichohyalin like 1; Belongs to the S-100 family. | 0.471 |
| FLG2 | FLG | ENSP00000373370 | ENSP00000357789 | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | 0.832 |
| FLG2 | RPTN | ENSP00000373370 | ENSP00000317895 | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. | 0.519 |
| FLG2 | S100A7 | ENSP00000373370 | ENSP00000357711 | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | S100 calcium binding protein A7. | 0.607 |
| FLG2 | TCHH | ENSP00000373370 | ENSP00000480484 | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network. It may be involved in its own calcium-dependent postsynthetic processing during terminal differentiation. | 0.660 |
| FLG2 | TCHHL1 | ENSP00000373370 | ENSP00000357796 | Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. In the N-terminal section; belongs to the S-100 family. | Trichohyalin-like protein 1; Trichohyalin like 1; Belongs to the S-100 family. | 0.419 |
| HRNR | FLG | ENSP00000357791 | ENSP00000357789 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. | 0.603 |
| HRNR | RPTN | ENSP00000357791 | ENSP00000317895 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium. | 0.442 |
| HRNR | S100A2 | ENSP00000357791 | ENSP00000499289 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May also play a role in suppressing tumor cell growth. | 0.738 |
| HRNR | S100A3 | ENSP00000357791 | ENSP00000357702 | Hornerin; Component of the epidermal cornified cell envelopes. Belongs to the S100-fused protein family. | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. | 0.762 |