(16 nodes) Elafin-like superfamily network (Homo sapiens)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	WFDC6	WAP four-disulfide core domain 6. (86 aa)
	WFDC2	WAP four-disulfide core domain protein 2; Broad range protease inhibitor. (124 aa)
	WFDC12	WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor. (111 aa)
	WFDC5	WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor. (123 aa)
	UMODL1	Uromodulin like 1. (1446 aa)
	EPPIN-WFDC6	EPPIN-WFDC6 readthrough. (179 aa)
	WFDC1	WAP four-disulfide core domain protein 1; Has growth inhibitory activity. (220 aa)
	WFIKKN1	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity (By similarity). (548 aa)
	WFIKKN2	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity); Belongs to the WFIKKN family. (576 aa)
	SLPI	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for no [...] (132 aa)
	ANOS1	Anosmin-1; Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. (680 aa)
	WFDC10A	WAP four-disulfide core domain 10A. (79 aa)
	WFDC8	WAP four-disulfide core domain 8. (241 aa)
	EPPIN	Eppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility. (133 aa)
	WFDC3	WAP four-disulfide core domain 3. (231 aa)
	PI3	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1). (117 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EPPIN	WFDC10A	ENSP00000361746	ENSP00000361726	Eppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.	WAP four-disulfide core domain 10A.	0.611
EPPIN	WFDC3	ENSP00000361746	ENSP00000243938	Eppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.	WAP four-disulfide core domain 3.	0.451
EPPIN-WFDC6	WFDC6	ENSP00000424176	ENSP00000361755	EPPIN-WFDC6 readthrough.	WAP four-disulfide core domain 6.	0.469
PI3	SLPI	ENSP00000243924	ENSP00000342082	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for no [...]	0.700
PI3	WFDC12	ENSP00000243924	ENSP00000361871	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).	WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor.	0.832
PI3	WFDC2	ENSP00000243924	ENSP00000361761	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).	WAP four-disulfide core domain protein 2; Broad range protease inhibitor.	0.420
PI3	WFDC5	ENSP00000243924	ENSP00000361875	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).	WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor.	0.572
PI3	WFDC8	ENSP00000243924	ENSP00000361735	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).	WAP four-disulfide core domain 8.	0.475
SLPI	PI3	ENSP00000342082	ENSP00000243924	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for no [...]	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).	0.700
SLPI	WFDC1	ENSP00000342082	ENSP00000456920	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for no [...]	WAP four-disulfide core domain protein 1; Has growth inhibitory activity.	0.646
SLPI	WFDC2	ENSP00000342082	ENSP00000361761	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for no [...]	WAP four-disulfide core domain protein 2; Broad range protease inhibitor.	0.648
SLPI	WFIKKN1	ENSP00000342082	ENSP00000324763	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for no [...]	WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease- inhibitor activity (By similarity).	0.554
WFDC1	SLPI	ENSP00000456920	ENSP00000342082	WAP four-disulfide core domain protein 1; Has growth inhibitory activity.	Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa- B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for no [...]	0.646
WFDC10A	EPPIN	ENSP00000361726	ENSP00000361746	WAP four-disulfide core domain 10A.	Eppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protection for spermatozoa in the ejaculate coagulum, and binds SEMG1 thereby inhibiting sperm motility.	0.611
WFDC10A	WFDC2	ENSP00000361726	ENSP00000361761	WAP four-disulfide core domain 10A.	WAP four-disulfide core domain protein 2; Broad range protease inhibitor.	0.473
WFDC10A	WFDC3	ENSP00000361726	ENSP00000243938	WAP four-disulfide core domain 10A.	WAP four-disulfide core domain 3.	0.598
WFDC10A	WFDC6	ENSP00000361726	ENSP00000361755	WAP four-disulfide core domain 10A.	WAP four-disulfide core domain 6.	0.596
WFDC10A	WFDC8	ENSP00000361726	ENSP00000361735	WAP four-disulfide core domain 10A.	WAP four-disulfide core domain 8.	0.639
WFDC12	PI3	ENSP00000361871	ENSP00000243924	WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor.	Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1).	0.832
WFDC12	WFDC2	ENSP00000361871	ENSP00000361761	WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor.	WAP four-disulfide core domain protein 2; Broad range protease inhibitor.	0.405