STRINGSTRING
SPTBN4 SPTBN4 SPTBN1 SPTBN1 PSD PSD PSD3 PSD3 PSD4 PSD4 PSD2 PSD2 SPTBN2 SPTBN2 ARHGAP23 ARHGAP23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPTBN4Spectrin beta chain, non-erythrocytic 4. (2564 aa)
SPTBN1Spectrin beta chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. (2364 aa)
PSDPH and SEC7 domain-containing protein 1; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity). Belongs to the PSD family. (1024 aa)
PSD3PH and SEC7 domain-containing protein 3; Guanine nucleotide exchange factor for ARF6. (1047 aa)
PSD4PH and SEC7 domain-containing protein 4; Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II- containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate. (1056 aa)
PSD2Pleckstrin and Sec7 domain containing 2. (771 aa)
SPTBN2Spectrin beta chain, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton; Belongs to the spectrin family. (2390 aa)
ARHGAP23Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. (1491 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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