(6 nodes) Hsp70 protein network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HSPA14-2	Heat shock 70kDa protein 14 isoform 1 variant 3. (143 aa)
	HSPA1A	Heat shock protein family A member 1A. (641 aa)
	HSPA1B	Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] (641 aa)
	HSPA4	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family. (840 aa)
	HSPA4L	Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family. (839 aa)
	HSPA13	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity. (471 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSPA13	HSPA14-2	ENSP00000285667	ENSP00000390513	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.	Heat shock 70kDa protein 14 isoform 1 variant 3.	0.826
HSPA13	HSPA1A	ENSP00000285667	ENSP00000364802	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.	Heat shock protein family A member 1A.	0.566
HSPA13	HSPA1B	ENSP00000285667	ENSP00000364801	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.	Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...]	0.566
HSPA13	HSPA4	ENSP00000285667	ENSP00000302961	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	0.758
HSPA13	HSPA4L	ENSP00000285667	ENSP00000296464	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.	Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family.	0.665
HSPA14-2	HSPA13	ENSP00000390513	ENSP00000285667	Heat shock 70kDa protein 14 isoform 1 variant 3.	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.	0.826
HSPA14-2	HSPA4	ENSP00000390513	ENSP00000302961	Heat shock 70kDa protein 14 isoform 1 variant 3.	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	0.574
HSPA1A	HSPA13	ENSP00000364802	ENSP00000285667	Heat shock protein family A member 1A.	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.	0.566
HSPA1A	HSPA1B	ENSP00000364802	ENSP00000364801	Heat shock protein family A member 1A.	Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...]	0.994
HSPA1A	HSPA4	ENSP00000364802	ENSP00000302961	Heat shock protein family A member 1A.	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	0.866
HSPA1A	HSPA4L	ENSP00000364802	ENSP00000296464	Heat shock protein family A member 1A.	Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family.	0.743
HSPA1B	HSPA13	ENSP00000364801	ENSP00000285667	Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...]	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.	0.566
HSPA1B	HSPA1A	ENSP00000364801	ENSP00000364802	Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...]	Heat shock protein family A member 1A.	0.994
HSPA1B	HSPA4	ENSP00000364801	ENSP00000302961	Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...]	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	0.939
HSPA1B	HSPA4L	ENSP00000364801	ENSP00000296464	Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...]	Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family.	0.749
HSPA4	HSPA13	ENSP00000302961	ENSP00000285667	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity.	0.758
HSPA4	HSPA14-2	ENSP00000302961	ENSP00000390513	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Heat shock 70kDa protein 14 isoform 1 variant 3.	0.574
HSPA4	HSPA1A	ENSP00000302961	ENSP00000364802	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Heat shock protein family A member 1A.	0.866
HSPA4	HSPA1B	ENSP00000302961	ENSP00000364801	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...]	0.939
HSPA4	HSPA4L	ENSP00000302961	ENSP00000296464	Heat shock protein family A member 4; Belongs to the heat shock protein 70 family.	Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family.	0.695