Your Input: | |||||
| LCTL | Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. (567 aa) | ||||
| LCT | Lactase-phlorizin hydrolase; LPH splits lactose in the small intestine. (1927 aa) | ||||
| KLB | Beta-klotho; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). (1044 aa) | ||||
| KL | Klotho peptide; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). (1012 aa) | ||||