STRINGSTRING
SSPN SSPN MS4A6A MS4A6A MS4A4E MS4A4E MS4A14 MS4A14 MS4A18 MS4A18 TMEM176A TMEM176A TMEM176B TMEM176B MS4A15 MS4A15 MS4A1 MS4A1 FAM189B FAM189B MS4A4A MS4A4A MS4A10 MS4A10 FAM189A2 FAM189A2 MS4A8 MS4A8 MS4A5 MS4A5 MS4A7 MS4A7 MS4A6E MS4A6E MS4A2 MS4A2 MS4A3 MS4A3 FAM189A1 FAM189A1 MS4A12 MS4A12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SSPNSarcospan; Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC. (243 aa)
MS4A6AMembrane-spanning 4-domains subfamily A member 6A; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (276 aa)
MS4A4EPutative membrane-spanning 4-domains subfamily A member 4E; Membrane spanning 4-domains A4E; Belongs to the MS4A family. (331 aa)
MS4A14Membrane-spanning 4-domains subfamily A member 14; May be involved in signal transduction as a component of a multimeric receptor complex. (712 aa)
MS4A18Membrane spanning 4-domains A18. (400 aa)
TMEM176ATransmembrane protein 176A. (235 aa)
TMEM176BTransmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity). (270 aa)
MS4A15Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex. (240 aa)
MS4A1B-lymphocyte antigen CD20; B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. Functions as a store-operated calcium (SOC) channel component promoting calcium influx after activation by the B-cell receptor/BCR. (297 aa)
FAM189BProtein FAM189B; Family with sequence similarity 189 member B. (668 aa)
MS4A4AMembrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex. (239 aa)
MS4A10Membrane-spanning 4-domains subfamily A member 10; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (267 aa)
FAM189A2Protein FAM189A2; Family with sequence similarity 189 member A2. (603 aa)
MS4A8Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex. (250 aa)
MS4A5Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex. (200 aa)
MS4A7Membrane-spanning 4-domains subfamily A member 7; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (240 aa)
MS4A6EMembrane-spanning 4-domains subfamily A member 6E; May be involved in signal transduction as a component of a multimeric receptor complex. (147 aa)
MS4A2High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor- bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy; Belongs to the MS4A family. (244 aa)
MS4A3Membrane-spanning 4-domains subfamily A member 3; Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin-dependent kinase 2 (CDK2) through its direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP); Belongs to the MS4A family. (214 aa)
FAM189A1Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family. (539 aa)
MS4A12Membrane-spanning 4-domains subfamily A member 12; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family. (267 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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