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| CTSD | Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. (412 aa) | ||||
| REN | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa) | ||||
| PGA5 | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. (388 aa) | ||||
| PGA3 | Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. (388 aa) | ||||
| CTSE | Cathepsin E form II; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Belongs to the peptidase A1 family. (396 aa) | ||||
| PGC | Gastricsin; Hydrolyzes a variety of proteins; Belongs to the peptidase A1 family. (388 aa) | ||||
| PGA4 | Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. (388 aa) | ||||
| ENSP00000489910 | Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (582 aa) | ||||