5 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCDC173	Coiled-coil domain containing 173. (552 aa)
	MNS1	Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family. (495 aa)
	TCHP	Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis ; Belongs to the TCHP family. (498 aa)
	CFAP45	Cilia and flagella associated protein 45. (551 aa)
	CFAP53	Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. (514 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC173	CFAP45	ENSP00000391504	ENSP00000357079	Coiled-coil domain containing 173.	Cilia and flagella associated protein 45.	0.854
CCDC173	CFAP53	ENSP00000391504	ENSP00000381553	Coiled-coil domain containing 173.	Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.	0.851
CCDC173	MNS1	ENSP00000391504	ENSP00000260453	Coiled-coil domain containing 173.	Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family.	0.838
CFAP45	CCDC173	ENSP00000357079	ENSP00000391504	Cilia and flagella associated protein 45.	Coiled-coil domain containing 173.	0.854
CFAP45	CFAP53	ENSP00000357079	ENSP00000381553	Cilia and flagella associated protein 45.	Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.	0.880
CFAP45	MNS1	ENSP00000357079	ENSP00000260453	Cilia and flagella associated protein 45.	Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family.	0.830
CFAP53	CCDC173	ENSP00000381553	ENSP00000391504	Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.	Coiled-coil domain containing 173.	0.851
CFAP53	CFAP45	ENSP00000381553	ENSP00000357079	Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.	Cilia and flagella associated protein 45.	0.880
CFAP53	MNS1	ENSP00000381553	ENSP00000260453	Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.	Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family.	0.902
MNS1	CCDC173	ENSP00000260453	ENSP00000391504	Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family.	Coiled-coil domain containing 173.	0.838
MNS1	CFAP45	ENSP00000260453	ENSP00000357079	Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family.	Cilia and flagella associated protein 45.	0.830
MNS1	CFAP53	ENSP00000260453	ENSP00000381553	Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis; Belongs to the MNS1 family.	Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis.	0.902