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MBD3L1 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor. (194 aa) | ||||
MBD3L2B | methyl-CpG binding domain protein 3 like 2B. (204 aa) | ||||
MBD3 | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases. (291 aa) | ||||
MBD3L4 | methyl-CpG binding domain protein 3 like 4. (208 aa) | ||||
MBD3L2 | methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family. (208 aa) | ||||
MBD3L3 | methyl-CpG binding domain protein 3 like 3. (208 aa) | ||||
MBD3L5 | methyl-CpG binding domain protein 3 like 5. (208 aa) | ||||
MBD2 | Methyl-CpG-binding domain protein 2; Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. (411 aa) |