node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFP | MAGEA1 | ENSP00000379138 | ENSP00000349085 | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties; Belongs to the ALB/AFP/VDB family. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.483 |
GAGE1 | MAGEA1 | ENSP00000484668 | ENSP00000349085 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.966 |
GAGE1 | MAGEA3 | ENSP00000484668 | ENSP00000473093 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.950 |
GAGE1 | MAGED4 | ENSP00000484668 | ENSP00000472118 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | MAGE family member D4. | 0.667 |
GAGE1 | MAGED4B | ENSP00000484668 | ENSP00000421861 | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | 0.666 |
MAGEA1 | AFP | ENSP00000349085 | ENSP00000379138 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties; Belongs to the ALB/AFP/VDB family. | 0.483 |
MAGEA1 | GAGE1 | ENSP00000349085 | ENSP00000484668 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | 0.966 |
MAGEA1 | MAGEA3 | ENSP00000349085 | ENSP00000473093 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.682 |
MAGEA3 | GAGE1 | ENSP00000473093 | ENSP00000484668 | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | 0.950 |
MAGEA3 | MAGEA1 | ENSP00000473093 | ENSP00000349085 | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.682 |
MAGED4 | GAGE1 | ENSP00000472118 | ENSP00000484668 | MAGE family member D4. | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | 0.667 |
MAGED4 | MAGED4B | ENSP00000472118 | ENSP00000421861 | MAGE family member D4. | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | 0.999 |
MAGED4B | GAGE1 | ENSP00000421861 | ENSP00000484668 | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | G antigen 1; Antigen, recognized on melanoma by autologous cytolytic T- lymphocytes. Completely silent in normal adult tissues, except testis; Belongs to the GAGE family. | 0.666 |
MAGED4B | MAGED4 | ENSP00000421861 | ENSP00000472118 | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | MAGE family member D4. | 0.999 |