| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1B1 | TALDO1 | ENSP00000285930 | ENSP00000321259 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.563 |
| AKR1B1 | TKT | ENSP00000285930 | ENSP00000391481 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. | 0.601 |
| AKR1B1 | TKTL1 | ENSP00000285930 | ENSP00000358931 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. | 0.519 |
| AKR1B1 | TKTL2 | ENSP00000285930 | ENSP00000280605 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | Transketolase-like protein 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis; Belongs to the transketolase family. | 0.612 |
| AKR1B1 | TPI1 | ENSP00000285930 | ENSP00000229270 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. | 0.607 |
| AKR1B1 | XYLB | ENSP00000285930 | ENSP00000207870 | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | Xylulose kinase; Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. | 0.670 |
| RPIA | TALDO1 | ENSP00000283646 | ENSP00000321259 | Ribose 5-phosphate isomerase A; Belongs to the ribose 5-phosphate isomerase family. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.998 |
| RPIA | TKT | ENSP00000283646 | ENSP00000391481 | Ribose 5-phosphate isomerase A; Belongs to the ribose 5-phosphate isomerase family. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. | 0.995 |
| RPIA | TKTL1 | ENSP00000283646 | ENSP00000358931 | Ribose 5-phosphate isomerase A; Belongs to the ribose 5-phosphate isomerase family. | Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. | 0.993 |
| RPIA | TKTL2 | ENSP00000283646 | ENSP00000280605 | Ribose 5-phosphate isomerase A; Belongs to the ribose 5-phosphate isomerase family. | Transketolase-like protein 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis; Belongs to the transketolase family. | 0.993 |
| RPIA | TPI1 | ENSP00000283646 | ENSP00000229270 | Ribose 5-phosphate isomerase A; Belongs to the ribose 5-phosphate isomerase family. | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. | 0.763 |
| RPIA | XYLB | ENSP00000283646 | ENSP00000207870 | Ribose 5-phosphate isomerase A; Belongs to the ribose 5-phosphate isomerase family. | Xylulose kinase; Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. | 0.678 |
| TALDO1 | AKR1B1 | ENSP00000321259 | ENSP00000285930 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | 0.563 |
| TALDO1 | RPIA | ENSP00000321259 | ENSP00000283646 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Ribose 5-phosphate isomerase A; Belongs to the ribose 5-phosphate isomerase family. | 0.998 |
| TALDO1 | TKT | ENSP00000321259 | ENSP00000391481 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. | 0.999 |
| TALDO1 | TKTL1 | ENSP00000321259 | ENSP00000358931 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. | 0.999 |
| TALDO1 | TKTL2 | ENSP00000321259 | ENSP00000280605 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Transketolase-like protein 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis; Belongs to the transketolase family. | 0.999 |
| TALDO1 | TPI1 | ENSP00000321259 | ENSP00000229270 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. | 0.994 |
| TALDO1 | XYLB | ENSP00000321259 | ENSP00000207870 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Xylulose kinase; Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. | 0.868 |
| TKT | AKR1B1 | ENSP00000391481 | ENSP00000285930 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family. | Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] | 0.601 |