node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BGN | DCN | ENSP00000327336 | ENSP00000052754 | Biglycan; May be involved in collagen fiber assembly. | Decorin; May affect the rate of fibrils formation. | 0.989 |
BGN | EFEMP2 | ENSP00000327336 | ENSP00000309953 | Biglycan; May be involved in collagen fiber assembly. | EGF containing fibulin extracellular matrix protein 2; Belongs to the fibulin family. | 0.726 |
BGN | EGF | ENSP00000327336 | ENSP00000265171 | Biglycan; May be involved in collagen fiber assembly. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro. | 0.621 |
BGN | ELN | ENSP00000327336 | ENSP00000351807 | Biglycan; May be involved in collagen fiber assembly. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). | 0.990 |
BGN | FBLN5 | ENSP00000327336 | ENSP00000345008 | Biglycan; May be involved in collagen fiber assembly. | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | 0.556 |
BGN | FBN1 | ENSP00000327336 | ENSP00000325527 | Biglycan; May be involved in collagen fiber assembly. | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] | 0.784 |
BGN | FBN2 | ENSP00000327336 | ENSP00000424571 | Biglycan; May be involved in collagen fiber assembly. | Fibrillin-2 C-terminal peptide; [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Belongs to the fibrillin family. | 0.532 |
BGN | MFAP2 | ENSP00000327336 | ENSP00000364685 | Biglycan; May be involved in collagen fiber assembly. | Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family. | 0.886 |
DCN | BGN | ENSP00000052754 | ENSP00000327336 | Decorin; May affect the rate of fibrils formation. | Biglycan; May be involved in collagen fiber assembly. | 0.989 |
DCN | EGF | ENSP00000052754 | ENSP00000265171 | Decorin; May affect the rate of fibrils formation. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro. | 0.917 |
DCN | ELN | ENSP00000052754 | ENSP00000351807 | Decorin; May affect the rate of fibrils formation. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). | 0.993 |
DCN | FBLN5 | ENSP00000052754 | ENSP00000345008 | Decorin; May affect the rate of fibrils formation. | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | 0.590 |
DCN | FBN1 | ENSP00000052754 | ENSP00000325527 | Decorin; May affect the rate of fibrils formation. | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] | 0.912 |
DCN | FBN2 | ENSP00000052754 | ENSP00000424571 | Decorin; May affect the rate of fibrils formation. | Fibrillin-2 C-terminal peptide; [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Belongs to the fibrillin family. | 0.603 |
DCN | MFAP2 | ENSP00000052754 | ENSP00000364685 | Decorin; May affect the rate of fibrils formation. | Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family. | 0.954 |
EFEMP2 | BGN | ENSP00000309953 | ENSP00000327336 | EGF containing fibulin extracellular matrix protein 2; Belongs to the fibulin family. | Biglycan; May be involved in collagen fiber assembly. | 0.726 |
EFEMP2 | EGF | ENSP00000309953 | ENSP00000265171 | EGF containing fibulin extracellular matrix protein 2; Belongs to the fibulin family. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro. | 0.453 |
EFEMP2 | ELN | ENSP00000309953 | ENSP00000351807 | EGF containing fibulin extracellular matrix protein 2; Belongs to the fibulin family. | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity). | 0.987 |
EFEMP2 | FBLN5 | ENSP00000309953 | ENSP00000345008 | EGF containing fibulin extracellular matrix protein 2; Belongs to the fibulin family. | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. | 0.837 |
EFEMP2 | FBN1 | ENSP00000309953 | ENSP00000325527 | EGF containing fibulin extracellular matrix protein 2; Belongs to the fibulin family. | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] | 0.873 |