5 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PRX	Periaxin; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. [...] (1461 aa)
	AHNAK2	AHNAK nucleoprotein 2. (5795 aa)
	AHNAK	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation. (5890 aa)
	CAPN3	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (821 aa)
	DYSF	Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family. (2119 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHNAK	AHNAK2	ENSP00000367263	ENSP00000353114	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	AHNAK nucleoprotein 2.	0.944
AHNAK	CAPN3	ENSP00000367263	ENSP00000380349	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family.	0.807
AHNAK	DYSF	ENSP00000367263	ENSP00000386881	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family.	0.982
AHNAK	PRX	ENSP00000367263	ENSP00000326018	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	Periaxin; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. [...]	0.941
AHNAK2	AHNAK	ENSP00000353114	ENSP00000367263	AHNAK nucleoprotein 2.	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	0.944
AHNAK2	CAPN3	ENSP00000353114	ENSP00000380349	AHNAK nucleoprotein 2.	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family.	0.455
AHNAK2	DYSF	ENSP00000353114	ENSP00000386881	AHNAK nucleoprotein 2.	Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family.	0.501
CAPN3	AHNAK	ENSP00000380349	ENSP00000367263	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family.	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	0.807
CAPN3	AHNAK2	ENSP00000380349	ENSP00000353114	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family.	AHNAK nucleoprotein 2.	0.455
CAPN3	DYSF	ENSP00000380349	ENSP00000386881	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family.	Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family.	0.985
DYSF	AHNAK	ENSP00000386881	ENSP00000367263	Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family.	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	0.982
DYSF	AHNAK2	ENSP00000386881	ENSP00000353114	Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family.	AHNAK nucleoprotein 2.	0.501
DYSF	CAPN3	ENSP00000386881	ENSP00000380349	Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity); Belongs to the ferlin family.	Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family.	0.985
PRX	AHNAK	ENSP00000326018	ENSP00000367263	Periaxin; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. [...]	Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation.	0.941