node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CTAG1B | CTAG2 | ENSP00000332602 | ENSP00000247306 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG1B | MAGEA1 | ENSP00000332602 | ENSP00000349085 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.910 |
CTAG1B | MAGEA10 | ENSP00000332602 | ENSP00000244096 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.785 |
CTAG1B | MAGEA3 | ENSP00000332602 | ENSP00000473093 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.974 |
CTAG1B | MAGEA4 | ENSP00000332602 | ENSP00000353379 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.946 |
CTAG1B | MAGEC1 | ENSP00000332602 | ENSP00000285879 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen C1; MAGE family member C1. | 0.842 |
CTAG1B | MAGED4 | ENSP00000332602 | ENSP00000472118 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | MAGE family member D4. | 0.695 |
CTAG1B | MAGED4B | ENSP00000332602 | ENSP00000421861 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | 0.698 |
CTAG1B | PMEL | ENSP00000332602 | ENSP00000402758 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. | 0.857 |
CTAG1B | SSX2 | ENSP00000332602 | ENSP00000338796 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | SSX family member 2. | 0.814 |
CTAG1B | TYR | ENSP00000332602 | ENSP00000263321 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family. | 0.861 |
CTAG2 | CTAG1B | ENSP00000247306 | ENSP00000332602 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG2 | MAGEA1 | ENSP00000247306 | ENSP00000349085 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.845 |
CTAG2 | MAGEA10 | ENSP00000247306 | ENSP00000244096 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.761 |
CTAG2 | MAGEA3 | ENSP00000247306 | ENSP00000473093 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.897 |
CTAG2 | MAGEA4 | ENSP00000247306 | ENSP00000353379 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. | 0.924 |
CTAG2 | MAGEC1 | ENSP00000247306 | ENSP00000285879 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen C1; MAGE family member C1. | 0.723 |
CTAG2 | MAGED4 | ENSP00000247306 | ENSP00000472118 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | MAGE family member D4. | 0.476 |
CTAG2 | MAGED4B | ENSP00000247306 | ENSP00000421861 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. | 0.474 |
CTAG2 | SSX2 | ENSP00000247306 | ENSP00000338796 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | SSX family member 2. | 0.709 |