7 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DCN	Decorin; May affect the rate of fibrils formation. (359 aa)
	OGN	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2. (298 aa)
	ALDH3A1	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity). (453 aa)
	LUM	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (338 aa)
	KERA	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. (352 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. (368 aa)
	FMOD	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (376 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH3A1	KERA	ENSP00000411821	ENSP00000266719	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	0.759
ALDH3A1	LUM	ENSP00000411821	ENSP00000266718	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.451
BGN	DCN	ENSP00000327336	ENSP00000052754	Biglycan; May be involved in collagen fiber assembly.	Decorin; May affect the rate of fibrils formation.	0.989
BGN	FMOD	ENSP00000327336	ENSP00000347041	Biglycan; May be involved in collagen fiber assembly.	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.976
BGN	LUM	ENSP00000327336	ENSP00000266718	Biglycan; May be involved in collagen fiber assembly.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.918
BGN	OGN	ENSP00000327336	ENSP00000364711	Biglycan; May be involved in collagen fiber assembly.	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	0.636
DCN	BGN	ENSP00000052754	ENSP00000327336	Decorin; May affect the rate of fibrils formation.	Biglycan; May be involved in collagen fiber assembly.	0.989
DCN	FMOD	ENSP00000052754	ENSP00000347041	Decorin; May affect the rate of fibrils formation.	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.938
DCN	KERA	ENSP00000052754	ENSP00000266719	Decorin; May affect the rate of fibrils formation.	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	0.647
DCN	LUM	ENSP00000052754	ENSP00000266718	Decorin; May affect the rate of fibrils formation.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.978
DCN	OGN	ENSP00000052754	ENSP00000364711	Decorin; May affect the rate of fibrils formation.	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	0.711
FMOD	BGN	ENSP00000347041	ENSP00000327336	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Biglycan; May be involved in collagen fiber assembly.	0.976
FMOD	DCN	ENSP00000347041	ENSP00000052754	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Decorin; May affect the rate of fibrils formation.	0.938
FMOD	KERA	ENSP00000347041	ENSP00000266719	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	0.576
FMOD	LUM	ENSP00000347041	ENSP00000266718	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.886
FMOD	OGN	ENSP00000347041	ENSP00000364711	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2.	0.818
KERA	ALDH3A1	ENSP00000266719	ENSP00000411821	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	0.759
KERA	DCN	ENSP00000266719	ENSP00000052754	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Decorin; May affect the rate of fibrils formation.	0.647
KERA	FMOD	ENSP00000266719	ENSP00000347041	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.576
KERA	LUM	ENSP00000266719	ENSP00000266718	Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.	Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.806