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RPL12 RPL12 RPL39 RPL39 RPL5 RPL5 GPX3 GPX3 GPX2 GPX2 RPS9 RPS9 RPL10A RPL10A RPS16 RPS16 RPS6KA3 RPS6KA3 RPL34 RPL34 RPS8 RPS8 RPS14 RPS14 RPL23A RPL23A RPSA RPSA GPX5 GPX5 RPL6 RPL6 RPL36A RPL36A RPS24 RPS24 RPL37A RPL37A GPX8 GPX8 RPLP2 RPLP2 RPS6KA1 RPS6KA1 SOD2-2 SOD2-2 RPL18 RPL18 RPLP0 RPLP0 RPL28 RPL28 RPL36 RPL36 RPS19 RPS19 RPS5 RPS5 RPS10 RPS10 RPL11 RPL11 RPS4X RPS4X MRPS18A MRPS18A RPL19 RPL19 MRPS7 MRPS7 RPL8 RPL8 RPS6KA6 RPS6KA6 RPL37 RPL37 RPS3 RPS3 RPL29 RPL29 MRPL4 MRPL4 MRPL38 MRPL38 MRPL1 MRPL1 HTR1A HTR1A MRPL54 MRPL54 RPL7 RPL7 MAOA MAOA RPS2 RPS2 RPL36AL RPL36AL RPLP1 RPLP1 RPL22L1 RPL22L1 MRPL52 MRPL52 RPS26 RPS26 GPX6 GPX6 GPX7 GPX7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPL1260S ribosomal protein L12; Binds directly to 26S ribosomal RNA. (165 aa)
RPL39Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family. (51 aa)
RPL560S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (297 aa)
GPX3Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. (226 aa)
GPX2Glutathione peroxidase 2; Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors. (190 aa)
RPS9Ribosomal protein S9. (194 aa)
RPL10A60S ribosomal protein L10a; Component of the large ribosomal subunit. (217 aa)
RPS16Ribosomal protein S16. (152 aa)
RPS6KA3Ribosomal protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subseq [...] (740 aa)
RPL3460S ribosomal protein L34; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL34 family. (117 aa)
RPS8Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (208 aa)
RPS14Ribosomal protein S14. (151 aa)
RPL23A60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA. May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination ; Belongs to the universal ribosomal protein uL23 family. (156 aa)
RPSA40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Dengue virus [...] (300 aa)
GPX5Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. (221 aa)
RPL660S ribosomal protein L6; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL6 family. (288 aa)
RPL36ARibosomal protein L36a. (142 aa)
RPS2440S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family. (289 aa)
RPL37ARibosomal protein L37a. (92 aa)
GPX8Glutathione peroxidase 8; Belongs to the glutathione peroxidase family. (209 aa)
RPLP260S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis. (115 aa)
RPS6KA1Ribosomal protein S6 kinase alpha-1; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activa [...] (744 aa)
SOD2-2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (176 aa)
RPL1860S ribosomal protein L18; Component of the large ribosomal subunit. (188 aa)
RPLP060S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (317 aa)
RPL2860S ribosomal protein L28; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL28 family. (170 aa)
RPL3660S ribosomal protein L36; Component of the large ribosomal subunit. (105 aa)
RPS1940S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family. (145 aa)
RPS540S ribosomal protein S5, N-terminally processed; Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family. (204 aa)
RPS1040S ribosomal protein S10; Component of the 40S ribosomal subunit; Belongs to the eukaryotic ribosomal protein eS10 family. (165 aa)
RPL1160S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] (178 aa)
RPS4XRibosomal protein S4 X-linked; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
MRPS18AMitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily. (196 aa)
RPL19Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (196 aa)
MRPS7Mitochondrial ribosomal protein S7. (242 aa)
RPL860S ribosomal protein L8; Component of the large ribosomal subunit. (257 aa)
RPS6KA6Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. (745 aa)
RPL3760S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (97 aa)
RPS340S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro- 8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (259 aa)
RPL2960S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family. (159 aa)
MRPL4Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family. (311 aa)
MRPL38Mitochondrial ribosomal protein L38; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily. (380 aa)
MRPL1Mitochondrial ribosomal protein L1. (325 aa)
HTR1A5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] (422 aa)
MRPL54Mitochondrial ribosomal protein L54. (138 aa)
RPL760S ribosomal protein L7; Component of the large ribosomal subunit. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs. (248 aa)
MAOAAmine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. (527 aa)
RPS2Ribosomal protein S2. (293 aa)
RPL36ALRibosomal protein L36a like; Belongs to the eukaryotic ribosomal protein eL42 family. (106 aa)
RPLP160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
RPL22L1Ribosomal protein L22 like 1; Belongs to the eukaryotic ribosomal protein eL22 family. (122 aa)
MRPL52Mitochondrial ribosomal protein L52. (123 aa)
RPS26Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family. (115 aa)
GPX6Glutathione peroxidase 6. (221 aa)
GPX7Glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks; Belongs to the glutathione peroxidase family. (187 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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