8 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LCE3C	Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. (94 aa)
	LCE3A	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family. (89 aa)
	LCE3B	Late cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. (95 aa)
	DACT1	Dapper homolog 1; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane l [...] (836 aa)
	LCE1B	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum. (118 aa)
	LCE3D	Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family. (92 aa)
	LCE3E	Late cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum. (92 aa)
	LCE1C	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family. (118 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LCE1B	LCE1C	ENSP00000353203	ENSP00000475270	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.988
LCE1B	LCE3A	ENSP00000353203	ENSP00000335006	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family.	0.800
LCE1B	LCE3B	ENSP00000353203	ENSP00000335358	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	Late cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.	0.797
LCE1B	LCE3C	ENSP00000353203	ENSP00000334644	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.	0.829
LCE1B	LCE3D	ENSP00000353203	ENSP00000357776	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.814
LCE1B	LCE3E	ENSP00000353203	ENSP00000357778	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	Late cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum.	0.804
LCE1C	LCE1B	ENSP00000475270	ENSP00000353203	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	0.988
LCE1C	LCE3A	ENSP00000475270	ENSP00000335006	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family.	0.848
LCE1C	LCE3B	ENSP00000475270	ENSP00000335358	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	Late cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.	0.806
LCE1C	LCE3C	ENSP00000475270	ENSP00000334644	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.	0.801
LCE1C	LCE3D	ENSP00000475270	ENSP00000357776	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.848
LCE1C	LCE3E	ENSP00000475270	ENSP00000357778	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	Late cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum.	0.892
LCE3A	LCE1B	ENSP00000335006	ENSP00000353203	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family.	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	0.800
LCE3A	LCE1C	ENSP00000335006	ENSP00000475270	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family.	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.848
LCE3A	LCE3B	ENSP00000335006	ENSP00000335358	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family.	Late cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.	0.778
LCE3A	LCE3C	ENSP00000335006	ENSP00000334644	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family.	Late cornified envelope protein 3C; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.	0.704
LCE3A	LCE3D	ENSP00000335006	ENSP00000357776	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family.	Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.898
LCE3A	LCE3E	ENSP00000335006	ENSP00000357778	Late cornified envelope protein 3A; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens ; Belongs to the LCE family.	Late cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum.	0.686
LCE3B	LCE1B	ENSP00000335358	ENSP00000353203	Late cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.	Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum.	0.797
LCE3B	LCE1C	ENSP00000335358	ENSP00000475270	Late cornified envelope protein 3B; A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens.	Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family.	0.806