(5 nodes) (1988) Proteases released in organ culture by acute dermal inflammatory lesions produced in vivo in rabbit skin by sulfur mustard: hydrolysis of synthetic peptide substrates for trypsin-like and chymotrypsin-like enzymes. network (Homo sapiens)

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Your Input:
	CTSG	Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. (255 aa)
	CTRB2	Chymotrypsinogen B2; Belongs to the peptidase S1 family. (263 aa)
	PLG	Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (810 aa)
	CTRB1	Chymotrypsinogen B1; Belongs to the peptidase S1 family. (263 aa)
	CTRL	Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family. (264 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTRB1	CTRB2	ENSP00000354294	ENSP00000303963	Chymotrypsinogen B1; Belongs to the peptidase S1 family.	Chymotrypsinogen B2; Belongs to the peptidase S1 family.	0.949
CTRB1	CTRL	ENSP00000354294	ENSP00000458537	Chymotrypsinogen B1; Belongs to the peptidase S1 family.	Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family.	0.831
CTRB1	CTSG	ENSP00000354294	ENSP00000216336	Chymotrypsinogen B1; Belongs to the peptidase S1 family.	Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.	0.764
CTRB1	PLG	ENSP00000354294	ENSP00000308938	Chymotrypsinogen B1; Belongs to the peptidase S1 family.	Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]	0.501
CTRB2	CTRB1	ENSP00000303963	ENSP00000354294	Chymotrypsinogen B2; Belongs to the peptidase S1 family.	Chymotrypsinogen B1; Belongs to the peptidase S1 family.	0.949
CTRB2	CTRL	ENSP00000303963	ENSP00000458537	Chymotrypsinogen B2; Belongs to the peptidase S1 family.	Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family.	0.832
CTRB2	CTSG	ENSP00000303963	ENSP00000216336	Chymotrypsinogen B2; Belongs to the peptidase S1 family.	Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.	0.622
CTRB2	PLG	ENSP00000303963	ENSP00000308938	Chymotrypsinogen B2; Belongs to the peptidase S1 family.	Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]	0.501
CTRL	CTRB1	ENSP00000458537	ENSP00000354294	Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family.	Chymotrypsinogen B1; Belongs to the peptidase S1 family.	0.831
CTRL	CTRB2	ENSP00000458537	ENSP00000303963	Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family.	Chymotrypsinogen B2; Belongs to the peptidase S1 family.	0.832
CTRL	CTSG	ENSP00000458537	ENSP00000216336	Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family.	Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.	0.421
CTSG	CTRB1	ENSP00000216336	ENSP00000354294	Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.	Chymotrypsinogen B1; Belongs to the peptidase S1 family.	0.764
CTSG	CTRB2	ENSP00000216336	ENSP00000303963	Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.	Chymotrypsinogen B2; Belongs to the peptidase S1 family.	0.622
CTSG	CTRL	ENSP00000216336	ENSP00000458537	Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.	Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family.	0.421
CTSG	PLG	ENSP00000216336	ENSP00000308938	Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.	Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]	0.533
PLG	CTRB1	ENSP00000308938	ENSP00000354294	Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]	Chymotrypsinogen B1; Belongs to the peptidase S1 family.	0.501
PLG	CTRB2	ENSP00000308938	ENSP00000303963	Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]	Chymotrypsinogen B2; Belongs to the peptidase S1 family.	0.501
PLG	CTSG	ENSP00000308938	ENSP00000216336	Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...]	Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.	0.533