6 items (human) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	HBA2	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues. (142 aa)
	HPX	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
	HBB	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family. (147 aa)
	CYGB	Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. (190 aa)
	HBA1	Hemoglobin subunit alpha 1. (142 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYGB	MB	ENSP00000293230	ENSP00000352835	Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.469
HBA1	HBA2	ENSP00000322421	ENSP00000251595	Hemoglobin subunit alpha 1.	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	0.999
HBA1	HBB	ENSP00000322421	ENSP00000494175	Hemoglobin subunit alpha 1.	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	0.999
HBA1	HPX	ENSP00000322421	ENSP00000265983	Hemoglobin subunit alpha 1.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.503
HBA2	HBA1	ENSP00000251595	ENSP00000322421	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemoglobin subunit alpha 1.	0.999
HBA2	HBB	ENSP00000251595	ENSP00000494175	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	0.999
HBA2	HPX	ENSP00000251595	ENSP00000265983	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.773
HBB	HBA1	ENSP00000494175	ENSP00000322421	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	Hemoglobin subunit alpha 1.	0.999
HBB	HBA2	ENSP00000494175	ENSP00000251595	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	0.999
HBB	HPX	ENSP00000494175	ENSP00000265983	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.819
HBB	MB	ENSP00000494175	ENSP00000352835	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.512
HPX	HBA1	ENSP00000265983	ENSP00000322421	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	Hemoglobin subunit alpha 1.	0.503
HPX	HBA2	ENSP00000265983	ENSP00000251595	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues.	0.773
HPX	HBB	ENSP00000265983	ENSP00000494175	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	0.819
HPX	MB	ENSP00000265983	ENSP00000352835	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.683
MB	CYGB	ENSP00000352835	ENSP00000293230	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer.	0.469
MB	HBB	ENSP00000352835	ENSP00000494175	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation; Belongs to the globin family.	0.512
MB	HPX	ENSP00000352835	ENSP00000265983	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.	0.683