(9 nodes) (2019) Bi-allelic Mutations in ARMC2 Lead to Severe Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in Humans and Mice. network (Homo sapiens)

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	SPEF2	Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. (1822 aa)
	WDR66	Cilia- and flagella-associated protein 251; Involved in spermatozoa motility. May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). (1149 aa)
	CFAP43	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function. (1665 aa)
	SPAG6	Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility. (509 aa)
	CFAP69	Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability. (941 aa)
	ARMC2	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity). (867 aa)
	CFAP44	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function. (1854 aa)
	FSIP2	Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis. (6907 aa)
	DNAH1	Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme ; Belongs to the dynein heavy chain family. (4265 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMC2	CFAP43	ENSP00000376417	ENSP00000349568	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	0.723
ARMC2	CFAP44	ENSP00000376417	ENSP00000377428	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	0.665
ARMC2	CFAP69	ENSP00000376417	ENSP00000373948	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability.	0.679
ARMC2	DNAH1	ENSP00000376417	ENSP00000401514	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme ; Belongs to the dynein heavy chain family.	0.649
ARMC2	FSIP2	ENSP00000376417	ENSP00000401306	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis.	0.607
ARMC2	SPEF2	ENSP00000376417	ENSP00000348314	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation.	0.717
ARMC2	WDR66	ENSP00000376417	ENSP00000288912	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	Cilia- and flagella-associated protein 251; Involved in spermatozoa motility. May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).	0.646
CFAP43	ARMC2	ENSP00000349568	ENSP00000376417	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	0.723
CFAP43	CFAP44	ENSP00000349568	ENSP00000377428	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	0.625
CFAP43	CFAP69	ENSP00000349568	ENSP00000373948	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability.	0.806
CFAP43	DNAH1	ENSP00000349568	ENSP00000401514	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme ; Belongs to the dynein heavy chain family.	0.790
CFAP43	FSIP2	ENSP00000349568	ENSP00000401306	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis.	0.686
CFAP43	SPAG6	ENSP00000349568	ENSP00000365811	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility.	0.530
CFAP43	SPEF2	ENSP00000349568	ENSP00000348314	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation.	0.735
CFAP43	WDR66	ENSP00000349568	ENSP00000288912	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	Cilia- and flagella-associated protein 251; Involved in spermatozoa motility. May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity).	0.807
CFAP44	ARMC2	ENSP00000377428	ENSP00000376417	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity).	0.665
CFAP44	CFAP43	ENSP00000377428	ENSP00000349568	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function.	0.625
CFAP44	CFAP69	ENSP00000377428	ENSP00000373948	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	Cilia- and flagella-associated protein 69; Cilium- and flagellum-associated protein. In the olfactory epithelium, regulates the speed of activation and termination of the odor response and thus contributes to the robustness of olfactory transduction pathways (By similarity). Required for sperm flagellum assembly and stability.	0.800
CFAP44	DNAH1	ENSP00000377428	ENSP00000401514	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme ; Belongs to the dynein heavy chain family.	0.784
CFAP44	FSIP2	ENSP00000377428	ENSP00000401306	Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function.	Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis.	0.664