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ZFAND4 ZFAND4 SPATA16 SPATA16 AKAP4 AKAP4 FAM209A FAM209A MARCHF6 MARCHF6 PLCZ1 PLCZ1 RNF17 RNF17 PKDREJ PKDREJ INHA INHA MORC1 MORC1 TULP2 TULP2 C9orf43 C9orf43 RHOXF2 RHOXF2 ESX1 ESX1 SEMG2 SEMG2 DMRT1 DMRT1 MAGEB16 MAGEB16 ROPN1L ROPN1L LOC100288966 LOC100288966 ZAN ZAN FAM71D FAM71D TBL1X TBL1X SLC9B1 SLC9B1 POTED POTED C9orf131 C9orf131 CATSPER1 CATSPER1 C12orf40 C12orf40 TMCO5A TMCO5A WBP2NL WBP2NL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZFAND4Zinc finger AN1-type containing 4. (727 aa)
SPATA16Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. (569 aa)
AKAP4A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; Belongs to the AKAP110 family. (854 aa)
FAM209AProtein FAM209A; Family with sequence similarity 209 member A. (171 aa)
MARCHF6E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. (910 aa)
PLCZ11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] (608 aa)
RNF17RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). (1623 aa)
PKDREJPolycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family. (2253 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family. (366 aa)
MORC1MORC family CW-type zinc finger protein 1; Required for spermatogenesis. (984 aa)
TULP2TUB like protein 2; Belongs to the TUB family. (520 aa)
C9orf43Uncharacterized protein C9orf43; Chromosome 9 open reading frame 43. (461 aa)
RHOXF2Rhox homeobox family member 2; Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogenesis. (288 aa)
ESX1Homeobox protein ESX1-C; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. (406 aa)
SEMG2Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa. (582 aa)
DMRT1Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and prom [...] (373 aa)
MAGEB16Melanoma-associated antigen B16; MAGE family member B16. (324 aa)
ROPN1LRopporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. (230 aa)
LOC100288966POTE ankyrin domain family member D-like. (584 aa)
ZANZonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling. (2812 aa)
FAM71DProtein FAM71D; Family with sequence similarity 71 member D. (422 aa)
TBL1XF-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. (577 aa)
SLC9B1Sodium/hydrogen exchanger 9B1; Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (515 aa)
POTEDPOTE ankyrin domain family member D; Belongs to the POTE family. (584 aa)
C9orf131Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131. (1079 aa)
CATSPER1Cation channel sperm-associated protein 1; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. (780 aa)
C12orf40Uncharacterized protein C12orf40; Chromosome 12 open reading frame 40. (652 aa)
TMCO5ATransmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family. (288 aa)
WBP2NLPostacrosomal sheath WW domain-binding protein; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. (309 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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