node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP5 | PITX1 | ENSP00000359866 | ENSP00000265340 | Bone morphogenetic protein 5; Induces cartilage and bone formation. | Pituitary homeobox 1; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Belongs to the paired homeobox family. Bicoid subfamily. | 0.504 |
CCNB1 | LIN37 | ENSP00000256442 | ENSP00000301159 | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component. | 0.664 |
CCNB1 | LIN52 | ENSP00000256442 | ENSP00000451812 | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | 0.637 |
CCNB1 | LIN54 | ENSP00000256442 | ENSP00000341947 | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence- specific manner. Specifically recognizes the consens [...] | 0.672 |
CCNB1 | LIN9 | ENSP00000256442 | ENSP00000329102 | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition; Belongs to the lin-9 family. | 0.722 |
CCNB1 | PCNA | ENSP00000256442 | ENSP00000368458 | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.867 |
CCNB1 | RBBP4 | ENSP00000256442 | ENSP00000362592 | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.643 |
LIN37 | CCNB1 | ENSP00000301159 | ENSP00000256442 | Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component. | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | 0.664 |
LIN37 | LIN52 | ENSP00000301159 | ENSP00000451812 | Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component. | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | 0.999 |
LIN37 | LIN54 | ENSP00000301159 | ENSP00000341947 | Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component. | Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence- specific manner. Specifically recognizes the consens [...] | 0.999 |
LIN37 | LIN9 | ENSP00000301159 | ENSP00000329102 | Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component. | Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition; Belongs to the lin-9 family. | 0.999 |
LIN37 | PCNA | ENSP00000301159 | ENSP00000368458 | Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.499 |
LIN37 | RBBP4 | ENSP00000301159 | ENSP00000362592 | Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component. | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.999 |
LIN52 | CCNB1 | ENSP00000451812 | ENSP00000256442 | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | 0.637 |
LIN52 | LIN37 | ENSP00000451812 | ENSP00000301159 | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component. | 0.999 |
LIN52 | LIN54 | ENSP00000451812 | ENSP00000341947 | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence- specific manner. Specifically recognizes the consens [...] | 0.999 |
LIN52 | LIN9 | ENSP00000451812 | ENSP00000329102 | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition; Belongs to the lin-9 family. | 0.999 |
LIN52 | PCNA | ENSP00000451812 | ENSP00000368458 | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.506 |
LIN52 | RBBP4 | ENSP00000451812 | ENSP00000362592 | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component. | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] | 0.999 |
LIN54 | CCNB1 | ENSP00000341947 | ENSP00000256442 | Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence- specific manner. Specifically recognizes the consens [...] | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily. | 0.672 |