STRINGSTRING
LUM LUM DCN DCN CHAD CHAD EPYC EPYC KERA KERA BGN BGN NYX NYX PRELP PRELP FMOD FMOD OPTC OPTC HSPG2 HSPG2 ASPN ASPN OMD OMD OGN OGN SDC1 SDC1 PODN PODN TSKU TSKU PODNL1 PODNL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LUMLumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (338 aa)
DCNDecorin; May affect the rate of fibrils formation. (359 aa)
CHADChondroadherin; Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily. (359 aa)
EPYCEpiphycan; May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (322 aa)
KERAKeratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. (352 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (368 aa)
NYXNyctalopin. (481 aa)
PRELPProlargin; May anchor basement membranes to the underlying connective tissue. (382 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (376 aa)
OPTCOpticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). (332 aa)
HSPG2Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require [...] (4391 aa)
ASPNAsporin; Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cart [...] (380 aa)
OMDOsteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity). (421 aa)
OGNMimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2. (298 aa)
SDC1Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. (310 aa)
PODNPodocan; Negatively regulates cell proliferation and cell migration. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class V subfamily. (661 aa)
TSKUTsukushin; Tsukushi, small leucine rich proteoglycan. (353 aa)
PODNL1Podocan-like protein 1; Podocan like 1. (510 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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