(4 nodes) (2024) Pyrroline-5-carboxylate metabolism protein complex detected in Arabidopsis thaliana leaf mitochondria. network (Homo sapiens)

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Your Input:
	PRODH	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (600 aa)
	OAT	Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase. (439 aa)
	ALDH4A1	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. (563 aa)
	LOC102724788	Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family. (600 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH4A1	LOC102724788	ENSP00000364490	ENSP00000481127	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.	Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family.	0.999
ALDH4A1	OAT	ENSP00000364490	ENSP00000357838	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.	Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase.	0.984
ALDH4A1	PRODH	ENSP00000364490	ENSP00000349577	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.999
LOC102724788	ALDH4A1	ENSP00000481127	ENSP00000364490	Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family.	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.	0.999
LOC102724788	OAT	ENSP00000481127	ENSP00000357838	Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family.	Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase.	0.951
LOC102724788	PRODH	ENSP00000481127	ENSP00000349577	Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.901
OAT	ALDH4A1	ENSP00000357838	ENSP00000364490	Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase.	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.	0.984
OAT	LOC102724788	ENSP00000357838	ENSP00000481127	Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase.	Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family.	0.951
OAT	PRODH	ENSP00000357838	ENSP00000349577	Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase.	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	0.951
PRODH	ALDH4A1	ENSP00000349577	ENSP00000364490	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.	0.999
PRODH	LOC102724788	ENSP00000349577	ENSP00000481127	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family.	0.901
PRODH	OAT	ENSP00000349577	ENSP00000357838	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate.	Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase.	0.951