STRINGSTRING
TEX49 TEX49 WBP11 WBP11 CFAP20 CFAP20 EFCAB6 EFCAB6 TEKT5 TEKT5 CFAP161 CFAP161 CCDC105 CCDC105 TEKT4 TEKT4 EFHB EFHB C9orf24 C9orf24 TEX37 TEX37 TUBA3E TUBA3E TUBA3D TUBA3D ENKUR ENKUR FAM166C FAM166C TUBA8 TUBA8 TUBA1B TUBA1B PACRG PACRG CFAP52 CFAP52 SPAG8 SPAG8 TEKT1 TEKT1 DUSP21 DUSP21 CFAP77 CFAP77 PPP1R32 PPP1R32 FAM166A FAM166A TEX43 TEX43 NME7 NME7 CFAP126 CFAP126 CFAP45 CFAP45 EFHC1 EFHC1 SPACA9 SPACA9 RIBC1 RIBC1 TUBAL3 TUBAL3 SAXO1 SAXO1 GP2 GP2 TEKT3 TEKT3 CFAP53 CFAP53 C9orf116 C9orf116 EFHC2 EFHC2 SERPINE2 SERPINE2 TUBA1A TUBA1A TUBA1C TUBA1C RIBC2 RIBC2 TEKT2 TEKT2 TUBA4A TUBA4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TEX49Testis-expressed protein 49; Testis expressed 49. (131 aa)
WBP11WW domain-binding protein 11; Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity. (641 aa)
CFAP20Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation. (193 aa)
EFCAB6EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex. (1501 aa)
TEKT5Tektin-5; May be a structural component of the sperm flagellum. (485 aa)
CFAP161Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly. (301 aa)
CCDC105Coiled-coil domain containing 105. (499 aa)
TEKT4Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility; Belongs to the tektin family. (435 aa)
EFHBEF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus. (833 aa)
C9orf24Spermatid-specific manchette-related protein 1; May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells. Belongs to the SMRP1 family. (262 aa)
TEX37Testis-expressed sequence 37 protein; Testis expressed 37. (180 aa)
TUBA3EDetyrosinated tubulin alpha-3E chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (450 aa)
TUBA3DDetyrosinated tubulin alpha-3C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
ENKUREnkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel. (256 aa)
FAM166CProtein FAM166C; Family with sequence similarity 166 member C; Belongs to the FAM166C family. (201 aa)
TUBA8Tubulin alpha-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
TUBA1BDetyrosinated tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
PACRGParkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. (296 aa)
CFAP52Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family. (620 aa)
SPAG8Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9. (501 aa)
TEKT1Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family. (418 aa)
DUSP21Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. (190 aa)
CFAP77Cilia and flagella associated protein 77. (320 aa)
PPP1R32Protein phosphatase 1 regulatory subunit 32. (425 aa)
FAM166AProtein FAM166A; Family with sequence similarity 166 member A. (317 aa)
TEX43Testis-expressed protein 43; Testis expressed 43. (134 aa)
NME7Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (376 aa)
CFAP126Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. Regulates kinocilium positioning and stereocilia bundle morphogenesis in the inner ear. (177 aa)
CFAP45Cilia and flagella associated protein 45. (551 aa)
EFHC1EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration. May enhance calcium influx through CACNA1E and stimulate programmed cell death. (640 aa)
SPACA9Sperm acrosome associated 9. (222 aa)
RIBC1RIB43A domain with coiled-coils 1; Belongs to the RIB43A family. (379 aa)
TUBAL3Tubulin alpha chain-like 3; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family. (446 aa)
SAXO1Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature. Belongs to the FAM154 family. (474 aa)
GP2Pancreatic secretory granule membrane major glycoprotein GP2; Glycoprotein 2. (537 aa)
TEKT3Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility. (490 aa)
CFAP53Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis. (514 aa)
C9orf116UPF0691 protein C9orf116; Chromosome 9 open reading frame 116. (136 aa)
EFHC2EF-hand domain-containing family member C2; EF-hand domain containing 2. (749 aa)
SERPINE2Glia-derived nexin; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin; Belongs to the serpin family. (409 aa)
TUBA1ADetyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
TUBA1CDetyrosinated tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (519 aa)
RIBC2RIB43A domain with coiled-coils 2. (382 aa)
TEKT2Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. (430 aa)
TUBA4ATubulin alpha-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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