node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IFI44 | IFI44L | ENSP00000359783 | ENSP00000359787 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | 0.999 |
IFI44 | IFIH1 | ENSP00000359783 | ENSP00000497271 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Interferon-induced helicase C domain-containing protein 1; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long- dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylat [...] | 0.954 |
IFI44 | IFIT1 | ENSP00000359783 | ENSP00000360869 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | 0.974 |
IFI44 | IFIT2 | ENSP00000359783 | ENSP00000490935 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylati [...] | 0.964 |
IFI44 | IFIT3 | ENSP00000359783 | ENSP00000360876 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B [...] | 0.984 |
IFI44 | MX1 | ENSP00000359783 | ENSP00000381601 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | Interferon-induced GTP-binding protein Mx1, N-terminally processed; Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing g [...] | 0.967 |
IFI44 | OAS1 | ENSP00000359783 | ENSP00000388001 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 2'-5'-oligoadenylate synthase 1; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition [...] | 0.961 |
IFI44 | OAS2 | ENSP00000359783 | ENSP00000342278 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivi [...] | 0.941 |
IFI44 | XAF1 | ENSP00000359783 | ENSP00000354822 | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | XIAP-associated factor 1; Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 fr [...] | 0.970 |
IFI44L | IFI44 | ENSP00000359787 | ENSP00000359783 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 0.999 |
IFI44L | IFIH1 | ENSP00000359787 | ENSP00000497271 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | Interferon-induced helicase C domain-containing protein 1; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long- dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylat [...] | 0.904 |
IFI44L | IFIT1 | ENSP00000359787 | ENSP00000360869 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | 0.967 |
IFI44L | IFIT2 | ENSP00000359787 | ENSP00000490935 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | Interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylati [...] | 0.921 |
IFI44L | IFIT3 | ENSP00000359787 | ENSP00000360876 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | Interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B [...] | 0.982 |
IFI44L | MX1 | ENSP00000359787 | ENSP00000381601 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | Interferon-induced GTP-binding protein Mx1, N-terminally processed; Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing g [...] | 0.965 |
IFI44L | OAS1 | ENSP00000359787 | ENSP00000388001 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | 2'-5'-oligoadenylate synthase 1; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition [...] | 0.955 |
IFI44L | OAS2 | ENSP00000359787 | ENSP00000342278 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivi [...] | 0.935 |
IFI44L | XAF1 | ENSP00000359787 | ENSP00000354822 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | XIAP-associated factor 1; Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 fr [...] | 0.981 |
IFIH1 | IFI44 | ENSP00000497271 | ENSP00000359783 | Interferon-induced helicase C domain-containing protein 1; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long- dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylat [...] | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 0.954 |
IFIH1 | IFI44L | ENSP00000497271 | ENSP00000359787 | Interferon-induced helicase C domain-containing protein 1; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long- dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylat [...] | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus. Belongs to the IFI44 family. | 0.904 |