STRINGSTRING
TECR TECR EEF1A2 EEF1A2 RPL19 RPL19 RPL8 RPL8 RPS2 RPS2 RPS21 RPS21 RPL27A RPL27A RPLP1 RPLP1 MAT1A MAT1A YRDC YRDC RPS4X RPS4X PUSL1 PUSL1 RPL13A RPL13A EEF1B2 EEF1B2 PCBP3 PCBP3 DQX1 DQX1 UBA52 UBA52 RPS18 RPS18 PEG10 PEG10 L1TD1 L1TD1 RACK1 RACK1 RPS13 RPS13 RPL18 RPL18 RPS27 RPS27
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TECRVery-long-chain enoyl-CoA reductase; Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl- CoA fatty acid intermediate to an acyl-CoA that can be furth [...] (308 aa)
EEF1A2Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (463 aa)
RPL19Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family. (196 aa)
RPL860S ribosomal protein L8; Component of the large ribosomal subunit. (257 aa)
RPS2Ribosomal protein S2. (293 aa)
RPS21Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family. (83 aa)
RPL27ARibosomal protein L27a; Belongs to the universal ribosomal protein uL15 family. (148 aa)
RPLP160S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa)
MAT1AS-adenosylmethionine synthase isoform type-1; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. (395 aa)
YRDCYrdC domain-containing protein, mitochondrial; May regulate the activity of some transporters. Belongs to the SUA5 family. (279 aa)
RPS4XRibosomal protein S4 X-linked; Belongs to the eukaryotic ribosomal protein eS4 family. (263 aa)
PUSL1Pseudouridine synthase like 1; Belongs to the tRNA pseudouridine synthase TruA family. (303 aa)
RPL13A60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppre [...] (203 aa)
EEF1B2Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. (225 aa)
PCBP3Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. (371 aa)
DQX1ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1. (717 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
RPS1840S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. (152 aa)
PEG10Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'- GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein ( [...] (401 aa)
L1TD1LINE1 type transposase domain containing 1. (865 aa)
RACK1Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits. Binds to and stabilizes activated protein [...] (317 aa)
RPS13Ribosomal protein S13. (151 aa)
RPL1860S ribosomal protein L18; Component of the large ribosomal subunit. (188 aa)
RPS2740S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs ; Belongs to the eukaryotic ribosomal protein eS27 family. (84 aa)
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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