(8 nodes) (2025) Bioinformatics analysis of comorbid mechanisms between ischemic stroke and end stage renal disease. network (Homo sapiens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	MRPS10	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family. (201 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	MRPS9	Mitochondrial ribosomal protein S9. (396 aa)
	MRPL49	Mitochondrial ribosomal protein L49. (166 aa)
	MRPS11	Mitochondrial ribosomal protein S11. (194 aa)
	TFB1M	Dimethyladenosine transferase 1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. (346 aa)
	MRPS2	28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family. (296 aa)
	MRPS27	28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Involved also in positive regulation of cell proliferation and tumor cell growth. (428 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MRPL49	MRPS10	ENSP00000279242	ENSP00000053468	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.	0.992
MRPL49	MRPS11	ENSP00000279242	ENSP00000317376	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein S11.	0.990
MRPL49	MRPS2	ENSP00000279242	ENSP00000360850	Mitochondrial ribosomal protein L49.	28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family.	0.975
MRPL49	MRPS27	ENSP00000279242	ENSP00000426941	Mitochondrial ribosomal protein L49.	28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Involved also in positive regulation of cell proliferation and tumor cell growth.	0.867
MRPL49	MRPS9	ENSP00000279242	ENSP00000258455	Mitochondrial ribosomal protein L49.	Mitochondrial ribosomal protein S9.	0.993
MRPS10	MRPL49	ENSP00000053468	ENSP00000279242	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.	Mitochondrial ribosomal protein L49.	0.992
MRPS10	MRPS11	ENSP00000053468	ENSP00000317376	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.	Mitochondrial ribosomal protein S11.	0.999
MRPS10	MRPS2	ENSP00000053468	ENSP00000360850	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.	28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family.	0.999
MRPS10	MRPS27	ENSP00000053468	ENSP00000426941	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.	28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Involved also in positive regulation of cell proliferation and tumor cell growth.	0.998
MRPS10	MRPS9	ENSP00000053468	ENSP00000258455	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.	Mitochondrial ribosomal protein S9.	0.999
MRPS10	TFB1M	ENSP00000053468	ENSP00000356134	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.	Dimethyladenosine transferase 1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.	0.930
MRPS11	MRPL49	ENSP00000317376	ENSP00000279242	Mitochondrial ribosomal protein S11.	Mitochondrial ribosomal protein L49.	0.990
MRPS11	MRPS10	ENSP00000317376	ENSP00000053468	Mitochondrial ribosomal protein S11.	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.	0.999
MRPS11	MRPS2	ENSP00000317376	ENSP00000360850	Mitochondrial ribosomal protein S11.	28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family.	0.999
MRPS11	MRPS27	ENSP00000317376	ENSP00000426941	Mitochondrial ribosomal protein S11.	28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Involved also in positive regulation of cell proliferation and tumor cell growth.	0.996
MRPS11	MRPS9	ENSP00000317376	ENSP00000258455	Mitochondrial ribosomal protein S11.	Mitochondrial ribosomal protein S9.	0.999
MRPS11	TFB1M	ENSP00000317376	ENSP00000356134	Mitochondrial ribosomal protein S11.	Dimethyladenosine transferase 1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.	0.912
MRPS2	MRPL49	ENSP00000360850	ENSP00000279242	28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family.	Mitochondrial ribosomal protein L49.	0.975
MRPS2	MRPS10	ENSP00000360850	ENSP00000053468	28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family.	Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family.	0.999
MRPS2	MRPS11	ENSP00000360850	ENSP00000317376	28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation; Belongs to the universal ribosomal protein uS2 family.	Mitochondrial ribosomal protein S11.	0.999