(6 nodes) (1976) Physiology and metabolism of pathogenic neisseria: tricarboxylic acid cycle activity in Neisseria gonorrhoeae. network (Homo sapiens)

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	IDH2	Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	ACO2	Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family. (780 aa)
	ACO1	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. (889 aa)
	MDH2	Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2. (338 aa)
	CS	Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family. (466 aa)
	IDH1	Isocitrate dehydrogenase 1. (414 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACO1	ACO2	ENSP00000309477	ENSP00000216254	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.	Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family.	0.943
ACO1	CS	ENSP00000309477	ENSP00000342056	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.	Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family.	0.999
ACO1	IDH1	ENSP00000309477	ENSP00000390265	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.	Isocitrate dehydrogenase 1.	0.998
ACO1	IDH2	ENSP00000309477	ENSP00000331897	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.	Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.998
ACO1	MDH2	ENSP00000309477	ENSP00000327070	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.	Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2.	0.893
ACO2	ACO1	ENSP00000216254	ENSP00000309477	Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family.	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.	0.943
ACO2	CS	ENSP00000216254	ENSP00000342056	Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family.	Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family.	0.999
ACO2	IDH1	ENSP00000216254	ENSP00000390265	Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family.	Isocitrate dehydrogenase 1.	0.998
ACO2	IDH2	ENSP00000216254	ENSP00000331897	Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family.	Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.998
ACO2	MDH2	ENSP00000216254	ENSP00000327070	Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family.	Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2.	0.951
CS	ACO1	ENSP00000342056	ENSP00000309477	Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family.	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.	0.999
CS	ACO2	ENSP00000342056	ENSP00000216254	Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family.	Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family.	0.999
CS	IDH1	ENSP00000342056	ENSP00000390265	Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family.	Isocitrate dehydrogenase 1.	0.993
CS	IDH2	ENSP00000342056	ENSP00000331897	Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family.	Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.994
CS	MDH2	ENSP00000342056	ENSP00000327070	Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family.	Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2.	0.999
IDH1	ACO1	ENSP00000390265	ENSP00000309477	Isocitrate dehydrogenase 1.	Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.	0.998
IDH1	ACO2	ENSP00000390265	ENSP00000216254	Isocitrate dehydrogenase 1.	Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family.	0.998
IDH1	CS	ENSP00000390265	ENSP00000342056	Isocitrate dehydrogenase 1.	Citrate synthase, mitochondrial; Citrate synthase; Belongs to the citrate synthase family.	0.993
IDH1	IDH2	ENSP00000390265	ENSP00000331897	Isocitrate dehydrogenase 1.	Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.961
IDH1	MDH2	ENSP00000390265	ENSP00000327070	Isocitrate dehydrogenase 1.	Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2.	0.970