(17 nodes) Galactoside-binding lectin network (Homo sapiens)

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	LGALS3	Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of [...] (250 aa)
	LGALS2	Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known. (132 aa)
	LGALS1	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. (135 aa)
	LGALS13	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes. (139 aa)
	CLC	Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg). (142 aa)
	LGALSL	Galectin-related protein; Does not bind lactose, and may not bind carbohydrates. (172 aa)
	LGALS4	Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions. (323 aa)
	LGALS7B	Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release. (136 aa)
	LGALS9B	Galectin-9B; Binds galactosides. (355 aa)
	LGALS9C	Galectin-9C; Binds galactosides. (356 aa)
	LGALS12	Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes. (337 aa)
	LGALS14	Placental protein 13-like; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. (168 aa)
	LGALS7	Galectin 7. (136 aa)
	LGALS16	Galectin-16; Binds lactose with high affinity. Strong inducer of T-cell apoptosis. (142 aa)
	LGALS9	Galectin-9; Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Ligand for CD44; [...] (355 aa)
	LGALS8	Galectin-8; Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruse [...] (359 aa)
	GRIFIN	Grifin; Galectin-related inter-fiber protein. (144 aa)

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLC	LGALS1	ENSP00000221804	ENSP00000215909	Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	0.437
CLC	LGALS12	ENSP00000221804	ENSP00000339374	Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).	Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes.	0.652
CLC	LGALS13	ENSP00000221804	ENSP00000221797	Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.	0.422
CLC	LGALS2	ENSP00000221804	ENSP00000215886	Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).	Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known.	0.709
CLC	LGALS3	ENSP00000221804	ENSP00000254301	Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).	Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of [...]	0.576
LGALS1	CLC	ENSP00000215909	ENSP00000221804	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).	0.437
LGALS1	LGALS13	ENSP00000215909	ENSP00000221797	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.	0.463
LGALS1	LGALS14	ENSP00000215909	ENSP00000353893	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	Placental protein 13-like; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis.	0.564
LGALS1	LGALS16	ENSP00000215909	ENSP00000375904	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	Galectin-16; Binds lactose with high affinity. Strong inducer of T-cell apoptosis.	0.458
LGALS1	LGALS2	ENSP00000215909	ENSP00000215886	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known.	0.674
LGALS1	LGALS3	ENSP00000215909	ENSP00000254301	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of [...]	0.735
LGALS1	LGALS8	ENSP00000215909	ENSP00000435460	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	Galectin-8; Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruse [...]	0.455
LGALS1	LGALS9	ENSP00000215909	ENSP00000378856	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	Galectin-9; Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Ligand for CD44; [...]	0.442
LGALS12	CLC	ENSP00000339374	ENSP00000221804	Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes.	Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).	0.652
LGALS12	LGALS13	ENSP00000339374	ENSP00000221797	Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes.	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.	0.665
LGALS12	LGALS9	ENSP00000339374	ENSP00000378856	Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes.	Galectin-9; Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Ligand for CD44; [...]	0.423
LGALS13	CLC	ENSP00000221797	ENSP00000221804	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.	Galectin-10; Regulates immune responses through the recognition of cell- surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).	0.422
LGALS13	LGALS1	ENSP00000221797	ENSP00000215909	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.	Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.	0.463
LGALS13	LGALS12	ENSP00000221797	ENSP00000339374	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.	Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes.	0.665
LGALS13	LGALS2	ENSP00000221797	ENSP00000215886	Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. Has hemagglutinating activity towards chicken erythrocytes.	Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known.	0.599