STRINGSTRING
FRS2 FRS2 GAB1 GAB1 GAB2 GAB2 AKT2 AKT2 FGFR1 FGFR1 PIK3R4 PIK3R4 IRS2 IRS2 FGF20 FGF20 TRIB3 TRIB3 PIK3CB PIK3CB PIK3R1 PIK3R1 PTPN11 PTPN11 FGF3 FGF3 FGF19 FGF19 THEM4 THEM4 FGF7 FGF7 PIK3R2 PIK3R2 FGF23 FGF23 FGFR4 FGFR4 PIK3C3 PIK3C3 FGF22 FGF22 TLR9-2 TLR9-2 KLB KLB FGF1 FGF1 FGF10 FGF10 FGF4 FGF4 FGF16 FGF16 FGF6 FGF6 FGF9 FGF9 FGFR3 FGFR3 PIK3CA PIK3CA FGF18 FGF18 GRB2 GRB2 FLT3 FLT3 PDPK1 PDPK1 FLT3LG FLT3LG FGF17 FGF17 FGFR2 FGFR2 PDE3B PDE3B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
GAB1GRB2 associated binding protein 1. (701 aa)
GAB2GRB2 associated binding protein 2. (663 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
FGFR1Fibroblast growth factor receptor. (853 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
IRS2Insulin receptor substrate 2. (1382 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
TRIB3Tribbles pseudokinase 3. (358 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
THEM4Thioesterase superfamily member 4. (409 aa)
FGF7Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity). (194 aa)
PIK3R2Uncharacterized protein. (726 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (312 aa)
FGFR4Fibroblast growth factor receptor. (860 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa)
TLR9-2Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
KLBKlotho beta. (1044 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
FGFR3Fibroblast growth factor receptor 3. (978 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (335 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1029 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (551 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (498 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
FGFR2Fibroblast growth factor receptor. (867 aa)
PDE3BPhosphodiesterase. (1069 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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