(29 nodes) Recognition of DNA damage by PCNA-containing replication complex network (Canis lupus familiaris)

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Your Input:
	UBE2B	Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	POLD2	DNA polymerase delta 2, accessory subunit. (519 aa)
	POLD1	DNA polymerase. (1107 aa)
	WDR48	WD repeat domain 48. (677 aa)
	RAD18	RAD18 E3 ubiquitin protein ligase. (503 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (761 aa)
	RFC5	Replication factor C subunit 5. (339 aa)
	CLCF1	Cardiotrophin like cytokine factor 1. (261 aa)
	DTL	Denticleless E3 ubiquitin protein ligase homolog. (730 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
	DDB1	Damage specific DNA binding protein 1. (1140 aa)
	USP1	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (785 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	POLE4	CBFD_NFYB_HMF domain-containing protein. (275 aa)
	ENSCAFP00000050780	Ubiquitin-like domain-containing protein. (151 aa)
	RFC2	Replication factor C subunit 2. (367 aa)
	POLE2	DNA polymerase epsilon 2, accessory subunit. (640 aa)
	RBX1	Ring-box 1. (108 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (1019 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2335 aa)
	RPA3	Uncharacterized protein. (351 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (187 aa)
	POLD3	DNA polymerase delta 3, accessory subunit. (541 aa)
	RPA2	Replication protein A2. (390 aa)
	RFC1	Replication factor C subunit 1. (1198 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLCF1	CUL4A	ENSCAFP00000017105	ENSCAFP00000009472	Cardiotrophin like cytokine factor 1.	Cullin 4A; Belongs to the cullin family.	0.499
CLCF1	CUL4B	ENSCAFP00000017105	ENSCAFP00000053406	Cardiotrophin like cytokine factor 1.	Cullin 4B; Belongs to the cullin family.	0.499
CLCF1	DDB1	ENSCAFP00000017105	ENSCAFP00000023980	Cardiotrophin like cytokine factor 1.	Damage specific DNA binding protein 1.	0.499
CLCF1	DTL	ENSCAFP00000017105	ENSCAFP00000018088	Cardiotrophin like cytokine factor 1.	Denticleless E3 ubiquitin protein ligase homolog.	0.499
CLCF1	ENSCAFP00000050780	ENSCAFP00000017105	ENSCAFP00000050780	Cardiotrophin like cytokine factor 1.	Ubiquitin-like domain-containing protein.	0.499
CLCF1	PCNA	ENSCAFP00000017105	ENSCAFP00000009045	Cardiotrophin like cytokine factor 1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.524
CLCF1	POLD1	ENSCAFP00000017105	ENSCAFP00000004374	Cardiotrophin like cytokine factor 1.	DNA polymerase.	0.953
CLCF1	POLD2	ENSCAFP00000017105	ENSCAFP00000004344	Cardiotrophin like cytokine factor 1.	DNA polymerase delta 2, accessory subunit.	0.953
CLCF1	POLD3	ENSCAFP00000017105	ENSCAFP00000061282	Cardiotrophin like cytokine factor 1.	DNA polymerase delta 3, accessory subunit.	0.965
CLCF1	POLE	ENSCAFP00000017105	ENSCAFP00000056044	Cardiotrophin like cytokine factor 1.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.552
CLCF1	POLE2	ENSCAFP00000017105	ENSCAFP00000051183	Cardiotrophin like cytokine factor 1.	DNA polymerase epsilon 2, accessory subunit.	0.417
CLCF1	POLE3	ENSCAFP00000017105	ENSCAFP00000058882	Cardiotrophin like cytokine factor 1.	DNA polymerase epsilon 3, accessory subunit.	0.421
CLCF1	POLE4	ENSCAFP00000017105	ENSCAFP00000047059	Cardiotrophin like cytokine factor 1.	CBFD_NFYB_HMF domain-containing protein.	0.400
CLCF1	RAD18	ENSCAFP00000017105	ENSCAFP00000008290	Cardiotrophin like cytokine factor 1.	RAD18 E3 ubiquitin protein ligase.	0.586
CLCF1	RBX1	ENSCAFP00000017105	ENSCAFP00000051832	Cardiotrophin like cytokine factor 1.	Ring-box 1.	0.499
CLCF1	RFC1	ENSCAFP00000017105	ENSCAFP00000063479	Cardiotrophin like cytokine factor 1.	Replication factor C subunit 1.	0.558
CLCF1	RFC2	ENSCAFP00000017105	ENSCAFP00000050887	Cardiotrophin like cytokine factor 1.	Replication factor C subunit 2.	0.509
CLCF1	RFC3	ENSCAFP00000017105	ENSCAFP00000009422	Cardiotrophin like cytokine factor 1.	Replication factor C subunit 3.	0.509
CLCF1	RFC4	ENSCAFP00000017105	ENSCAFP00000020162	Cardiotrophin like cytokine factor 1.	Replication factor C subunit 4.	0.509
CLCF1	RFC5	ENSCAFP00000017105	ENSCAFP00000014551	Cardiotrophin like cytokine factor 1.	Replication factor C subunit 5.	0.509