(18 nodes) Translesion Synthesis by POLH network (Canis lupus familiaris)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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textmining

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Your Input:
	POLH	DNA polymerase eta. (712 aa)
	VCP	Valosin containing protein; Belongs to the AAA ATPase family. (806 aa)
	NPLOC4	NPL4 homolog, ubiquitin recognition factor. (615 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	RFC5	Replication factor C subunit 5. (339 aa)
	SPRTN	SprT-like N-terminal domain. (487 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (307 aa)
	RCHY1	Ring finger and CHY zinc finger domain containing 1. (259 aa)
	ENSCAFP00000050780	Ubiquitin-like domain-containing protein. (151 aa)
	RFC2	Replication factor C subunit 2. (367 aa)
	RPA3	Uncharacterized protein. (351 aa)
	RPA2	Replication protein A2. (390 aa)
	RFC1	Replication factor C subunit 1. (1198 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000050780	NPLOC4	ENSCAFP00000050780	ENSCAFP00000008625	Ubiquitin-like domain-containing protein.	NPL4 homolog, ubiquitin recognition factor.	0.857
ENSCAFP00000050780	PCNA	ENSCAFP00000050780	ENSCAFP00000009045	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.867
ENSCAFP00000050780	POLH	ENSCAFP00000050780	ENSCAFP00000002810	Ubiquitin-like domain-containing protein.	DNA polymerase eta.	0.752
ENSCAFP00000050780	RCHY1	ENSCAFP00000050780	ENSCAFP00000038785	Ubiquitin-like domain-containing protein.	Ring finger and CHY zinc finger domain containing 1.	0.585
ENSCAFP00000050780	RFC1	ENSCAFP00000050780	ENSCAFP00000063479	Ubiquitin-like domain-containing protein.	Replication factor C subunit 1.	0.506
ENSCAFP00000050780	RFC2	ENSCAFP00000050780	ENSCAFP00000050887	Ubiquitin-like domain-containing protein.	Replication factor C subunit 2.	0.518
ENSCAFP00000050780	RFC3	ENSCAFP00000050780	ENSCAFP00000009422	Ubiquitin-like domain-containing protein.	Replication factor C subunit 3.	0.518
ENSCAFP00000050780	RFC4	ENSCAFP00000050780	ENSCAFP00000020162	Ubiquitin-like domain-containing protein.	Replication factor C subunit 4.	0.518
ENSCAFP00000050780	RFC5	ENSCAFP00000050780	ENSCAFP00000014551	Ubiquitin-like domain-containing protein.	Replication factor C subunit 5.	0.518
ENSCAFP00000050780	RPA1	ENSCAFP00000050780	ENSCAFP00000028391	Ubiquitin-like domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.513
ENSCAFP00000050780	RPA2	ENSCAFP00000050780	ENSCAFP00000061592	Ubiquitin-like domain-containing protein.	Replication protein A2.	0.629
ENSCAFP00000050780	RPA3	ENSCAFP00000050780	ENSCAFP00000056239	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.542
ENSCAFP00000050780	RPS27A	ENSCAFP00000050780	ENSCAFP00000031429	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.405
ENSCAFP00000050780	SPRTN	ENSCAFP00000050780	ENSCAFP00000017335	Ubiquitin-like domain-containing protein.	SprT-like N-terminal domain.	0.542
ENSCAFP00000050780	UBA52	ENSCAFP00000050780	ENSCAFP00000021714	Ubiquitin-like domain-containing protein.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.972
ENSCAFP00000050780	UFD1	ENSCAFP00000050780	ENSCAFP00000038321	Ubiquitin-like domain-containing protein.	Ubiquitin recognition factor in ER associated degradation 1.	0.816
ENSCAFP00000050780	VCP	ENSCAFP00000050780	ENSCAFP00000002927	Ubiquitin-like domain-containing protein.	Valosin containing protein; Belongs to the AAA ATPase family.	0.745
NPLOC4	ENSCAFP00000050780	ENSCAFP00000008625	ENSCAFP00000050780	NPL4 homolog, ubiquitin recognition factor.	Ubiquitin-like domain-containing protein.	0.857
NPLOC4	PCNA	ENSCAFP00000008625	ENSCAFP00000009045	NPL4 homolog, ubiquitin recognition factor.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.507
NPLOC4	POLH	ENSCAFP00000008625	ENSCAFP00000002810	NPL4 homolog, ubiquitin recognition factor.	DNA polymerase eta.	0.504