(30 nodes) Neurotransmitter release cycle network (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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Your Input:
	GLS2	Glutaminase 2. (603 aa)
	SLC22A2	Solute carrier family 22 member 2. (533 aa)
	APBA1	Amyloid beta precursor protein binding family A member 1. (929 aa)
	SLC5A7	Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (578 aa)
	SLC1A1	Amino acid transporter. (524 aa)
	SLC17A7	Solute carrier family 17 member 7. (560 aa)
	GAD2	Glutamate decarboxylase 2; Catalyzes the production of GABA. (585 aa)
	SLC6A1	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
	SYT1	Synaptotagmin 1. (422 aa)
	ARL6IP5	PRA1 family protein. (188 aa)
	SLC18A3	Solute carrier family 18 member A3. (510 aa)
	SLC32A1	Solute carrier family 32 member 1. (526 aa)
	GLS	Glutaminase. (754 aa)
	LIN7C	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
	SLC18A2	Solute carrier family 18 member A2. (669 aa)
	SLC6A12	Sodium- and chloride-dependent betaine transporter; Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily. (614 aa)
	SLC1A3	Amino acid transporter. (542 aa)
	SLC1A7	Amino acid transporter. (574 aa)
	CHAT	Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (665 aa)
	GAD1	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family. (595 aa)
	VAMP2	V-SNARE coiled-coil homology domain-containing protein. (116 aa)
	SLC38A2	Solute carrier family 38 member 2. (573 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
	SLC1A2	Amino acid transporter. (629 aa)
	LIN7B	Lin-7 homolog B, crumbs cell polarity complex component. (499 aa)
	ABAT	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	RAB3A	RAB3A, member RAS oncogene family. (220 aa)
	ALDH5A1	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (473 aa)
	LIN7A	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (228 aa)
	SLC6A11	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (669 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABAT	ALDH5A1	ENSCAFP00000053240	ENSCAFP00000062405	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.988
ABAT	GAD1	ENSCAFP00000053240	ENSCAFP00000039685	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family.	0.685
ABAT	GAD2	ENSCAFP00000053240	ENSCAFP00000006413	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamate decarboxylase 2; Catalyzes the production of GABA.	0.963
ABAT	SLC5A7	ENSCAFP00000053240	ENSCAFP00000003044	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.528
ALDH5A1	ABAT	ENSCAFP00000062405	ENSCAFP00000053240	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.988
ALDH5A1	GAD1	ENSCAFP00000062405	ENSCAFP00000039685	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family.	0.666
ALDH5A1	GAD2	ENSCAFP00000062405	ENSCAFP00000006413	Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Glutamate decarboxylase 2; Catalyzes the production of GABA.	0.558
APBA1	CASK	ENSCAFP00000002781	ENSCAFP00000044853	Amyloid beta precursor protein binding family A member 1.	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	0.985
APBA1	LIN7A	ENSCAFP00000002781	ENSCAFP00000062478	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.782
APBA1	LIN7B	ENSCAFP00000002781	ENSCAFP00000050073	Amyloid beta precursor protein binding family A member 1.	Lin-7 homolog B, crumbs cell polarity complex component.	0.702
APBA1	LIN7C	ENSCAFP00000002781	ENSCAFP00000014981	Amyloid beta precursor protein binding family A member 1.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.702
ARL6IP5	SLC1A1	ENSCAFP00000009784	ENSCAFP00000003046	PRA1 family protein.	Amino acid transporter.	0.445
CASK	APBA1	ENSCAFP00000044853	ENSCAFP00000002781	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Amyloid beta precursor protein binding family A member 1.	0.985
CASK	LIN7A	ENSCAFP00000044853	ENSCAFP00000062478	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.956
CASK	LIN7B	ENSCAFP00000044853	ENSCAFP00000050073	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Lin-7 homolog B, crumbs cell polarity complex component.	0.941
CASK	LIN7C	ENSCAFP00000044853	ENSCAFP00000014981	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.	0.950
CASK	SLC5A7	ENSCAFP00000044853	ENSCAFP00000003044	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.	Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.421
CHAT	SLC18A2	ENSCAFP00000036125	ENSCAFP00000017607	Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family.	Solute carrier family 18 member A2.	0.487
CHAT	SLC18A3	ENSCAFP00000036125	ENSCAFP00000009900	Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family.	Solute carrier family 18 member A3.	0.920
CHAT	SLC5A7	ENSCAFP00000036125	ENSCAFP00000003044	Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family.	Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.	0.411