STRINGSTRING
TEC TEC KIT KIT GRB10 GRB10 FYN FYN PIK3R3 PIK3R3 GAB2 GAB2 SOS1 SOS1 PIK3R1 PIK3R1 SH2B3 SH2B3 PTPN11 PTPN11 NRAS NRAS CHEK1 CHEK1 LCK LCK PRKCA PRKCA FES FES CMA1 CMA1 PIK3R2 PIK3R2 STAT5A STAT5A STAT5B STAT5B GRB7 GRB7 VAV1 VAV1 HRAS HRAS SH2B2 SH2B2 PTPN6 PTPN6 JAK2 JAK2 SRC SRC CBL CBL LYN LYN PIK3CA PIK3CA STAT1 STAT1 GRB2 GRB2 STAT3 STAT3 LOC489534 LOC489534 KRAS KRAS GRAP2 GRAP2 KITLG KITLG PTPRU PTPRU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TECTyrosine-protein kinase. (631 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
GRB10Growth factor receptor bound protein 10. (546 aa)
FYNTyrosine-protein kinase. (589 aa)
PIK3R3Uncharacterized protein. (461 aa)
GAB2GRB2 associated binding protein 2. (663 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1353 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
SH2B3SH2B adaptor protein 3. (586 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
NRASUncharacterized protein. (189 aa)
CHEK1Checkpoint kinase 1. (454 aa)
LCKTyrosine-protein kinase. (509 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (619 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (820 aa)
CMA1Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. (249 aa)
PIK3R2Uncharacterized protein. (726 aa)
STAT5ASignal transducer and activator of transcription. (794 aa)
STAT5BSignal transducer and activator of transcription. (787 aa)
GRB7Growth factor receptor bound protein 7. (553 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
HRASUncharacterized protein. (189 aa)
SH2B2SH2B adaptor protein 2. (626 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (620 aa)
JAK2Janus kinase 2. (1407 aa)
SRCTyrosine-protein kinase. (553 aa)
CBLCbl proto-oncogene. (895 aa)
LYNTyrosine-protein kinase. (566 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
STAT1Signal transducer and activator of transcription. (774 aa)
GRB2Growth factor receptor bound protein 2. (250 aa)
STAT3Signal transducer and activator of transcription. (793 aa)
LOC489534Uncharacterized protein. (282 aa)
KRASKRAS proto-oncogene, GTPase. (283 aa)
GRAP2GRB2 related adaptor protein 2. (547 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins. (335 aa)
PTPRUProtein tyrosine phosphatase receptor type U. (1452 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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