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PIP4K2C PIP4K2C PIP5K1B PIP5K1B INPP4A INPP4A INPP4B INPP4B RAB14 RAB14 PIK3CG PIK3CG PIP4K2A PIP4K2A PIK3R3 PIK3R3 MTMR14 MTMR14 INPPL1 INPPL1 RAB5A RAB5A PIK3CB PIK3CB PIK3R1 PIK3R1 MTMR9 MTMR9 PLEKHA6 PLEKHA6 PIK3C2B PIK3C2B ARF1 ARF1 MTMR3 MTMR3 PIP5K1A PIP5K1A INPP5J INPP5J PIK3R2 PIK3R2 PI4K2B PI4K2B PIK3R6 PIK3R6 PIK3R5 PIK3R5 OCRL OCRL MTM1 MTM1 INPP5K INPP5K PIP5K1C PIP5K1C PIK3CD PIK3CD PLEKHA2 PLEKHA2 RUFY1 RUFY1 PIK3C2A PIK3C2A MTMR1 MTMR1 PLEKHA4 PLEKHA4 PLEKHA3 PLEKHA3 PTEN PTEN SYNJ2 SYNJ2 RAB4A RAB4A MTMR6 MTMR6 PIK3CA PIK3CA SYNJ1 SYNJ1 PLEKHA8 PLEKHA8 PIK3C2G PIK3C2G PLEKHA5 PLEKHA5 INPP5D INPP5D PLEKHA1 PLEKHA1 PGAM1 PGAM1 BMX BMX PIP4K2B PIP4K2B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (352 aa)
PIP5K1BPhosphatidylinositol-4-phosphate 5-kinase type 1 beta. (543 aa)
INPP4AInositol polyphosphate-4-phosphatase type I A. (978 aa)
INPP4BInositol polyphosphate-4-phosphatase type II B. (944 aa)
RAB14RAB14, member RAS oncogene family. (215 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1104 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (406 aa)
PIK3R3Uncharacterized protein. (461 aa)
MTMR14Myotubularin related protein 14. (648 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
MTMR9Myotubularin related protein 9. (549 aa)
PLEKHA6Pleckstrin homology domain containing A6. (1171 aa)
PIK3C2BPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1634 aa)
ARF1Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (181 aa)
MTMR3Myotubularin related protein 3. (1062 aa)
PIP5K1APIPK domain-containing protein. (562 aa)
INPP5JInositol polyphosphate-5-phosphatase J. (1008 aa)
PIK3R2Uncharacterized protein. (726 aa)
PI4K2BPhosphatidylinositol 4-kinase type 2 beta. (440 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (874 aa)
OCRLOCRL inositol polyphosphate-5-phosphatase. (881 aa)
MTM1Myotubularin 1. (654 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (452 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (663 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1083 aa)
PLEKHA2Pleckstrin homology domain containing A2. (425 aa)
RUFY1RUN and FYVE domain containing 1. (744 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1693 aa)
MTMR1Myotubularin related protein 1. (638 aa)
PLEKHA4Pleckstrin homology domain containing A4. (778 aa)
PLEKHA3Pleckstrin homology domain containing A3. (379 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
SYNJ2Synaptojanin 2. (1526 aa)
RAB4ARAB4A, member RAS oncogene family. (228 aa)
MTMR6Myotubularin related protein 6. (779 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SYNJ1Uncharacterized protein. (1574 aa)
PLEKHA8Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non- vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation [...] (552 aa)
PIK3C2GPhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1477 aa)
PLEKHA5Pleckstrin homology domain containing A5. (1284 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1501 aa)
PLEKHA1Pleckstrin homology domain containing A1. (404 aa)
PGAM1PI3K/PI4K domain-containing protein. (569 aa)
BMXTyrosine-protein kinase. (710 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (441 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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