STRINGSTRING
TICAM2 TICAM2 TAB2 TAB2 TAB1 TAB1 LRRC14 LRRC14 PPP2R5D PPP2R5D MAP3K7 MAP3K7 PELI1 PELI1 VRK3 VRK3 IRAK2 IRAK2 NKIRAS1 NKIRAS1 PIK3R4 PIK3R4 DUSP6 DUSP6 EEA1 EEA1 PPP2CB PPP2CB TRAF6 TRAF6 RIPK2 RIPK2 MAPK10 MAPK10 CHUK CHUK N4BP1 N4BP1 NFKB2 NFKB2 MAPKAPK3 MAPKAPK3 TIFA TIFA ALPK1 ALPK1 CASP8 CASP8 NLRX1 NLRX1 S100B S100B RPS6KA1 RPS6KA1 RPS6KA3 RPS6KA3 RELA RELA ATF2 ATF2 NFKBIA NFKBIA CREB1 CREB1 TAB3 TAB3 PPP2R1B PPP2R1B UBA52 UBA52 PELI2 PELI2 FOS FOS MAPK3 MAPK3 ECSIT ECSIT RPS6KA5 RPS6KA5 PIK3C3 PIK3C3 MAPK7 MAPK7 USP14 USP14 TRAF2 TRAF2 IKBKG IKBKG TLR9-2 TLR9-2 MAPK1 MAPK1 TLR4 TLR4 RPS27A RPS27A PPP2CA PPP2CA TICAM1 TICAM1 NKIRAS2 NKIRAS2 MAP2K7 MAP2K7 UBE2N-2 UBE2N-2 DUSP3 DUSP3 HMGB1 HMGB1 DUSP4 DUSP4 UBE2V1 UBE2V1 NFKBIB NFKBIB S100A12 S100A12 PELI3 PELI3 LY96 LY96 MAP3K1 MAP3K1 NLRC5 NLRC5 IRAK1 IRAK1 MAPK8 MAPK8 IKBKB IKBKB MAPK14 MAPK14 MAP2K4 MAP2K4 ATF1 ATF1 ENSCAFP00000050780 ENSCAFP00000050780 RPS6KA2 RPS6KA2 RBSN RBSN NFKB1 NFKB1 MAP2K6 MAP2K6 USP18 USP18 MAP2K3 MAP2K3 AGER AGER MAPK11 MAPK11 MAPK9 MAPK9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TICAM2TIR domain-containing protein. (238 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (680 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
VRK3VRK serine/threonine kinase 3. (455 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1358 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
EEA1Early endosome antigen 1. (1406 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
MAPK10Mitogen-activated protein kinase. (467 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
N4BP1NEDD4 binding protein 1. (874 aa)
NFKB2Nuclear factor kappa B subunit 2. (899 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (381 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
ALPK1Alpha kinase 1. (1237 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (486 aa)
NLRX1NLR family member X1. (975 aa)
S100BProtein S100; Belongs to the S-100 family. (92 aa)
RPS6KA1Non-specific serine/threonine protein kinase. (876 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (717 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (771 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
PELI2Pellino E3 ubiquitin protein ligase family member 2. (563 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK3Mitogen-activated protein kinase. (283 aa)
ECSITECSIT signalling integrator. (433 aa)
RPS6KA5Ribosomal protein S6 kinase. (793 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (900 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (806 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (545 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
TLR9-2Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1032 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (360 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PPP2CASerine/threonine-protein phosphatase. (310 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (751 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (435 aa)
UBE2N-2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (240 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (147 aa)
NFKBIBNFKB inhibitor beta. (357 aa)
S100A12Protein S100; Belongs to the S-100 family. (92 aa)
PELI3E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (469 aa)
LY96Lymphocyte antigen 96. (160 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1671 aa)
NLRC5NLR family CARD domain containing 5. (1859 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (750 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
MAPK14Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] (360 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (413 aa)
ATF1Activating transcription factor 1. (429 aa)
ENSCAFP00000050780Ubiquitin-like domain-containing protein. (151 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
RBSNRabenosyn, RAB effector. (792 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (336 aa)
USP18Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (581 aa)
MAP2K3Mitogen-activated protein kinase kinase 3. (517 aa)
AGERAdvanced glycosylation end product-specific receptor variant C. (396 aa)
MAPK11Mitogen-activated protein kinase. (231 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.