STRINGSTRING
EP300 EP300 TLE1 TLE1 TLE4 TLE4 RUVBL1 RUVBL1 TCF7L1 TCF7L1 H2BC1 H2BC1 BCL9 BCL9 H2AJ H2AJ LOC486670 LOC486670 MEN1 MEN1 PYGO1 PYGO1 PYGO2 PYGO2 TLE2 TLE2 H2AX H2AX LOC482202 LOC482202 LOC102152481 LOC102152481 CREBBP CREBBP LOC478743 LOC478743 HDAC1 HDAC1 J9NWQ8_CANLF J9NWQ8_CANLF H2BC21 H2BC21 J9P0B2_CANLF J9P0B2_CANLF TLE3 TLE3 LOC483168 LOC483168 LOC611231 LOC611231 TCF7L2 TCF7L2 H2BC18 H2BC18 LOC612779 LOC612779 LOC488289 LOC488289 H2AC6 H2AC6 LOC488290 LOC488290 LOC111090006 LOC111090006 RBBP5 RBBP5 TCF7 TCF7 LOC488263 LOC488263 LEO1 LEO1 TRRAP TRRAP LOC488264 LOC488264 ENSCAFP00000046288 ENSCAFP00000046288 ASH2L ASH2L H2BC10 H2BC10 BCL9L BCL9L KMT2D KMT2D LEF1 LEF1 CDC73 CDC73 SMARCA4 SMARCA4 KAT5 KAT5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EP300E1A binding protein p300. (2308 aa)
TLE1TLE family member 1, transcriptional corepressor. (762 aa)
TLE4TLE family member 4, transcriptional corepressor. (712 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (129 aa)
LOC486670Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
MEN1Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the [...] (686 aa)
PYGO1Pygopus family PHD finger 1. (417 aa)
PYGO2Pygopus family PHD finger 2. (405 aa)
TLE2TLE family member 2, transcriptional corepressor. (743 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
LOC482202Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC102152481Uncharacterized protein. (403 aa)
CREBBPCREB binding protein. (2442 aa)
LOC478743Histone H2B; Belongs to the histone H2B family. (126 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (508 aa)
J9NWQ8_CANLFHistone H2A; Belongs to the histone H2A family. (96 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
J9P0B2_CANLFHistone domain-containing protein; Belongs to the histone H2B family. (277 aa)
TLE3TLE family member 3, transcriptional corepressor. (733 aa)
LOC483168Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC611231Histone H2A; Belongs to the histone H2A family. (128 aa)
TCF7L2Transcription factor 7 like 2. (565 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (135 aa)
LOC612779Histone H3; Belongs to the histone H3 family. (136 aa)
LOC488289Histone H2A; Belongs to the histone H2A family. (130 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC488290Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC111090006Histone H3; Belongs to the histone H3 family. (136 aa)
RBBP5RB binding protein 5, histone lysine methyltransferase complex subunit. (553 aa)
TCF7Transcription factor 7. (484 aa)
LOC488263Histone H3; Belongs to the histone H3 family. (136 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (708 aa)
TRRAPTransformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3872 aa)
LOC488264Histone H2B; Belongs to the histone H2B family. (435 aa)
ENSCAFP00000046288Histone H2B; Belongs to the histone H2B family. (177 aa)
ASH2LASH2 like, histone lysine methyltransferase complex subunit. (634 aa)
H2BC10Histone H2B; Belongs to the histone H2B family. (126 aa)
BCL9LBCL9 like. (1481 aa)
KMT2DLysine methyltransferase 2D. (5763 aa)
LEF1Lymphoid enhancer binding factor 1. (481 aa)
CDC73Cell division cycle 73. (565 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1647 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (579 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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