STRINGSTRING
MALT1 MALT1 TAB2 TAB2 HLA-DQB2 HLA-DQB2 DLA-DQA1 DLA-DQA1 HLA-DQB1 HLA-DQB1 F1PSQ5_CANLF F1PSQ5_CANLF SKP1 SKP1 PSME4 PSME4 MAP3K7 MAP3K7 CUL1 CUL1 PSMB2 PSMB2 PSMD5 PSMD5 E2QRQ7_CANLF E2QRQ7_CANLF PSMC2 PSMC2 PRKCQ PRKCQ PSMC4 PSMC4 TRAF6 TRAF6 PSMF1 PSMF1 PIK3CB PIK3CB PIK3R1 PIK3R1 PSMD9 PSMD9 PSMC3 PSMC3 RIPK2 RIPK2 CHUK CHUK PSMD14 PSMD14 LCK LCK TRAV29DV5 TRAV29DV5 PSMB5 PSMB5 PSME1 PSME1 PSMA7 PSMA7 PSMD4 PSMD4 PSMD2 PSMD2 PSMB4 PSMB4 PSMC5 PSMC5 CD3G CD3G RELA RELA PSMA6 PSMA6 NFKBIA NFKBIA UBA52 UBA52 PIK3R2 PIK3R2 PSMB6 PSMB6 PSMD3 PSMD3 CARD11 CARD11 PSMB3 PSMB3 PSMC1 PSMC1 PSMA8 PSMA8 PSMD11 PSMD11 IKBKG IKBKG PSMA5 PSMA5 BCL10 BCL10 PSMB10 PSMB10 PSMB1 PSMB1 RPS27A RPS27A PSMD10 PSMD10 TRBV12-5 TRBV12-5 E2R820_CANLF E2R820_CANLF PSMD13 PSMD13 PSMD12 PSMD12 UBE2D2 UBE2D2 UBE2D1 UBE2D1 PSMB9 PSMB9 CD3D CD3D CDC34 CDC34 LOC100687259 LOC100687259 J9P2T7_CANLF J9P2T7_CANLF UBE2N-2 UBE2N-2 PSMD7 PSMD7 UBE2V1 UBE2V1 CD247 CD247 PSMA3 PSMA3 TRAT1 TRAT1 FBXW11 FBXW11 TRAV19 TRAV19 PTEN PTEN DLA-DRA DLA-DRA ENSCAFP00000047134 ENSCAFP00000047134 ENSCAFP00000047147 ENSCAFP00000047147 IKBKB IKBKB PIK3CA PIK3CA PSMA4 PSMA4 PSMC6 PSMC6 ENSCAFP00000050780 ENSCAFP00000050780 CD3E CD3E PDPK1 PDPK1 PSMB7 PSMB7 NFKB1 NFKB1 INPP5D INPP5D PSMA2 PSMA2 PSME2 PSME2 CD4 CD4 PSMD1 PSMD1 PSMA1 PSMA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MALT1MALT1 paracaspase. (758 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
HLA-DQB2Major histocompatibility complex, class II, DQ beta 1. (205 aa)
DLA-DQA1Ig-like domain-containing protein; Belongs to the MHC class II family. (344 aa)
HLA-DQB1Major histocompatibility complex, class II, DQ beta 2. (303 aa)
F1PSQ5_CANLFUncharacterized protein. (228 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
PSME4Proteasome activator subunit 4. (1762 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD5Uncharacterized protein. (500 aa)
E2QRQ7_CANLFIg-like domain-containing protein. (186 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (715 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
PSMD9Proteasome 26S subunit, non-ATPase 9. (223 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (308 aa)
LCKTyrosine-protein kinase. (509 aa)
TRAV29DV5T cell receptor alpha variable 29/delta variable 5 (gene/pseudogene). (155 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMA7Proteasome endopeptidase complex. (178 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
CD3GCD3g molecule. (182 aa)
RELARELA proto-oncogene, NF-kB subunit. (542 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
PIK3R2Uncharacterized protein. (726 aa)
PSMB6Proteasome subunit beta. (239 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
CARD11Caspase recruitment domain family member 11. (1154 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
PSMB10Proteasome subunit beta. (272 aa)
PSMB1Proteasome subunit beta. (241 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
TRBV12-5T cell receptor beta variable 12-5. (146 aa)
E2R820_CANLFDUF1968 domain-containing protein. (139 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
UBE2D2Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
UBE2D1Ubiquitin conjugating enzyme E2 D1; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
PSMB9Proteasome subunit beta. (209 aa)
CD3DCD3d molecule. (194 aa)
CDC34Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (236 aa)
LOC100687259AAA domain-containing protein; Belongs to the AAA ATPase family. (365 aa)
J9P2T7_CANLFUncharacterized protein. (461 aa)
UBE2N-2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
UBE2V1Ubiquitin conjugating enzyme E2 V1. (147 aa)
CD247Uncharacterized protein. (199 aa)
PSMA3Proteasome endopeptidase complex. (257 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (186 aa)
FBXW11F-box and WD repeat domain containing 11. (657 aa)
TRAV19Ig-like domain-containing protein. (132 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
DLA-DRAIg-like domain-containing protein; Belongs to the MHC class II family. (342 aa)
ENSCAFP00000047134Proteasome endopeptidase complex. (216 aa)
ENSCAFP00000047147IG domain-containing protein. (129 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PSMA4Proteasome subunit alpha 4. (290 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
ENSCAFP00000050780Ubiquitin-like domain-containing protein. (151 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (228 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (551 aa)
PSMB7Proteasome subunit beta. (315 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] (1015 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1501 aa)
PSMA2Proteasome subunit alpha type. (295 aa)
PSME2Proteasome activator subunit 2. (253 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (462 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
PSMA1Proteasome subunit alpha type. (267 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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