(12 nodes) p75NTR recruits signalling complexes network (Canis lupus familiaris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	MYD88	MYD88 innate immune signal transduction adaptor. (398 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (580 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
	NGF	Nerve growth factor; Belongs to the NGF-beta family. (240 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
	PRKCI	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	NGFR	Nerve growth factor receptor. (429 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (750 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (756 aa)
	ENSCAFP00000050780	Ubiquitin-like domain-containing protein. (151 aa)
	SQSTM1	Sequestosome 1. (551 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000050780	IKBKB	ENSCAFP00000050780	ENSCAFP00000048001	Ubiquitin-like domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.536
ENSCAFP00000050780	IRAK1	ENSCAFP00000050780	ENSCAFP00000047467	Ubiquitin-like domain-containing protein.	Interleukin 1 receptor associated kinase 1.	0.532
ENSCAFP00000050780	NGF	ENSCAFP00000050780	ENSCAFP00000014297	Ubiquitin-like domain-containing protein.	Nerve growth factor; Belongs to the NGF-beta family.	0.499
ENSCAFP00000050780	NGFR	ENSCAFP00000050780	ENSCAFP00000042847	Ubiquitin-like domain-containing protein.	Nerve growth factor receptor.	0.499
ENSCAFP00000050780	RPS27A	ENSCAFP00000050780	ENSCAFP00000031429	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.405
ENSCAFP00000050780	SQSTM1	ENSCAFP00000050780	ENSCAFP00000065910	Ubiquitin-like domain-containing protein.	Sequestosome 1.	0.745
ENSCAFP00000050780	TRAF6	ENSCAFP00000050780	ENSCAFP00000010159	Ubiquitin-like domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.985
ENSCAFP00000050780	UBA52	ENSCAFP00000050780	ENSCAFP00000021714	Ubiquitin-like domain-containing protein.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.972
IKBKB	ENSCAFP00000050780	ENSCAFP00000048001	ENSCAFP00000050780	Inhibitor of nuclear factor kappa B kinase subunit beta.	Ubiquitin-like domain-containing protein.	0.536
IKBKB	IRAK1	ENSCAFP00000048001	ENSCAFP00000047467	Inhibitor of nuclear factor kappa B kinase subunit beta.	Interleukin 1 receptor associated kinase 1.	0.657
IKBKB	MYD88	ENSCAFP00000048001	ENSCAFP00000007386	Inhibitor of nuclear factor kappa B kinase subunit beta.	MYD88 innate immune signal transduction adaptor.	0.572
IKBKB	NGF	ENSCAFP00000048001	ENSCAFP00000014297	Inhibitor of nuclear factor kappa B kinase subunit beta.	Nerve growth factor; Belongs to the NGF-beta family.	0.560
IKBKB	NGFR	ENSCAFP00000048001	ENSCAFP00000042847	Inhibitor of nuclear factor kappa B kinase subunit beta.	Nerve growth factor receptor.	0.623
IKBKB	RPS27A	ENSCAFP00000048001	ENSCAFP00000031429	Inhibitor of nuclear factor kappa B kinase subunit beta.	Ubiquitin-like domain-containing protein.	0.538
IKBKB	SQSTM1	ENSCAFP00000048001	ENSCAFP00000065910	Inhibitor of nuclear factor kappa B kinase subunit beta.	Sequestosome 1.	0.621
IKBKB	TRAF6	ENSCAFP00000048001	ENSCAFP00000010159	Inhibitor of nuclear factor kappa B kinase subunit beta.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.975
IKBKB	UBA52	ENSCAFP00000048001	ENSCAFP00000021714	Inhibitor of nuclear factor kappa B kinase subunit beta.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.572
IRAK1	ENSCAFP00000050780	ENSCAFP00000047467	ENSCAFP00000050780	Interleukin 1 receptor associated kinase 1.	Ubiquitin-like domain-containing protein.	0.532
IRAK1	IKBKB	ENSCAFP00000047467	ENSCAFP00000048001	Interleukin 1 receptor associated kinase 1.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.657
IRAK1	MYD88	ENSCAFP00000047467	ENSCAFP00000007386	Interleukin 1 receptor associated kinase 1.	MYD88 innate immune signal transduction adaptor.	0.999