27 items (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Predicted Interactions

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Your Input:
	YWHAZ	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (236 aa)
	CBY1	Chibby family member 1, beta catenin antagonist. (127 aa)
	TLE1	TLE family member 1, transcriptional corepressor. (762 aa)
	TLE4	TLE family member 4, transcriptional corepressor. (712 aa)
	XPO1	Exportin 1. (1071 aa)
	AKT2	AKT serine/threonine kinase 2. (557 aa)
	TCF7L1	Transcription factor 7 like 1. (588 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (423 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	SOX3	SRY-box 3. (444 aa)
	TLE2	TLE family member 2, transcriptional corepressor. (743 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	SOX7	Uncharacterized protein. (311 aa)
	SOX4	Transcription factor SOX. (344 aa)
	XIAP	Baculoviral IAP-repeat containing protein 4. (493 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (508 aa)
	SOX17	SRY-box 17. (418 aa)
	TLE3	TLE family member 3, transcriptional corepressor. (733 aa)
	TCF7L2	Transcription factor 7 like 2. (565 aa)
	TCF7	Transcription factor 7. (484 aa)
	CHD8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2625 aa)
	APC	APC regulator of WNT signaling pathway. (2851 aa)
	SOX13	SRY-box 13. (618 aa)
	ENSCAFP00000050780	Ubiquitin-like domain-containing protein. (151 aa)
	SOX6	SRY-box 6. (889 aa)
	LEF1	Lymphoid enhancer binding factor 1. (481 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSCAFP00000027133	ENSCAFP00000008032	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	AKT serine/threonine kinase 2.	0.906
AKT1	CBY1	ENSCAFP00000027133	ENSCAFP00000001974	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Chibby family member 1, beta catenin antagonist.	0.750
AKT1	XIAP	ENSCAFP00000027133	ENSCAFP00000034255	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Baculoviral IAP-repeat containing protein 4.	0.450
AKT2	AKT1	ENSCAFP00000008032	ENSCAFP00000027133	AKT serine/threonine kinase 2.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.906
AKT2	CBY1	ENSCAFP00000008032	ENSCAFP00000001974	AKT serine/threonine kinase 2.	Chibby family member 1, beta catenin antagonist.	0.750
APC	CTBP1	ENSCAFP00000048524	ENSCAFP00000024542	APC regulator of WNT signaling pathway.	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.928
APC	ENSCAFP00000050780	ENSCAFP00000048524	ENSCAFP00000050780	APC regulator of WNT signaling pathway.	Ubiquitin-like domain-containing protein.	0.500
APC	HDAC1	ENSCAFP00000048524	ENSCAFP00000036819	APC regulator of WNT signaling pathway.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.422
APC	LEF1	ENSCAFP00000048524	ENSCAFP00000056485	APC regulator of WNT signaling pathway.	Lymphoid enhancer binding factor 1.	0.595
APC	RPS27A	ENSCAFP00000048524	ENSCAFP00000031429	APC regulator of WNT signaling pathway.	Ubiquitin-like domain-containing protein.	0.500
APC	TCF7	ENSCAFP00000048524	ENSCAFP00000043629	APC regulator of WNT signaling pathway.	Transcription factor 7.	0.918
APC	TCF7L1	ENSCAFP00000048524	ENSCAFP00000011603	APC regulator of WNT signaling pathway.	Transcription factor 7 like 1.	0.918
APC	TCF7L2	ENSCAFP00000048524	ENSCAFP00000039879	APC regulator of WNT signaling pathway.	Transcription factor 7 like 2.	0.919
APC	TLE1	ENSCAFP00000048524	ENSCAFP00000002118	APC regulator of WNT signaling pathway.	TLE family member 1, transcriptional corepressor.	0.403
APC	TLE2	ENSCAFP00000048524	ENSCAFP00000028496	APC regulator of WNT signaling pathway.	TLE family member 2, transcriptional corepressor.	0.409
APC	TLE3	ENSCAFP00000048524	ENSCAFP00000038992	APC regulator of WNT signaling pathway.	TLE family member 3, transcriptional corepressor.	0.409
APC	TLE4	ENSCAFP00000048524	ENSCAFP00000002238	APC regulator of WNT signaling pathway.	TLE family member 4, transcriptional corepressor.	0.414
APC	UBA52	ENSCAFP00000048524	ENSCAFP00000021714	APC regulator of WNT signaling pathway.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.499
CBY1	AKT1	ENSCAFP00000001974	ENSCAFP00000027133	Chibby family member 1, beta catenin antagonist.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.750
CBY1	AKT2	ENSCAFP00000001974	ENSCAFP00000008032	Chibby family member 1, beta catenin antagonist.	AKT serine/threonine kinase 2.	0.750