STRINGSTRING
YWHAZ YWHAZ CBY1 CBY1 TLE1 TLE1 TLE4 TLE4 XPO1 XPO1 AKT2 AKT2 TCF7L1 TCF7L1 UBA52 UBA52 CTBP1 CTBP1 AKT1 AKT1 SOX3 SOX3 TLE2 TLE2 RPS27A RPS27A SOX7 SOX7 SOX4 SOX4 XIAP XIAP HDAC1 HDAC1 SOX17 SOX17 TLE3 TLE3 TCF7L2 TCF7L2 TCF7 TCF7 CHD8 CHD8 APC APC SOX13 SOX13 ENSCAFP00000050780 ENSCAFP00000050780 SOX6 SOX6 LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
YWHAZ14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (236 aa)
CBY1Chibby family member 1, beta catenin antagonist. (127 aa)
TLE1TLE family member 1, transcriptional corepressor. (762 aa)
TLE4TLE family member 4, transcriptional corepressor. (712 aa)
XPO1Exportin 1. (1071 aa)
AKT2AKT serine/threonine kinase 2. (557 aa)
TCF7L1Transcription factor 7 like 1. (588 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (423 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SOX3SRY-box 3. (444 aa)
TLE2TLE family member 2, transcriptional corepressor. (743 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
SOX7Uncharacterized protein. (311 aa)
SOX4Transcription factor SOX. (344 aa)
XIAPBaculoviral IAP-repeat containing protein 4. (493 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (508 aa)
SOX17SRY-box 17. (418 aa)
TLE3TLE family member 3, transcriptional corepressor. (733 aa)
TCF7L2Transcription factor 7 like 2. (565 aa)
TCF7Transcription factor 7. (484 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2625 aa)
APCAPC regulator of WNT signaling pathway. (2851 aa)
SOX13SRY-box 13. (618 aa)
ENSCAFP00000050780Ubiquitin-like domain-containing protein. (151 aa)
SOX6SRY-box 6. (889 aa)
LEF1Lymphoid enhancer binding factor 1. (481 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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