STRINGSTRING
PCNA PCNA RFC3 RFC3 POLK POLK RFC5 RFC5 RFC4 RFC4 UBA52 UBA52 MAD2L2 MAD2L2 RPA1 RPA1 RPS27A RPS27A ENSCAFP00000050780 ENSCAFP00000050780 RFC2 RFC2 REV3L REV3L AFF3 AFF3 RPA3 RPA3 RPA2 RPA2 RFC1 RFC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RFC3Replication factor C subunit 3. (356 aa)
POLKDNA polymerase kappa. (861 aa)
RFC5Replication factor C subunit 5. (339 aa)
RFC4Replication factor C subunit 4. (363 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (196 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
ENSCAFP00000050780Ubiquitin-like domain-containing protein. (151 aa)
RFC2Replication factor C subunit 2. (367 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3121 aa)
AFF3DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1346 aa)
RPA3Uncharacterized protein. (351 aa)
RPA2Replication protein A2. (390 aa)
RFC1Replication factor C subunit 1. (1198 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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