STRINGSTRING
MDC1 MDC1 LOC100685589 LOC100685589 MRE11 MRE11 PAXIP1 PAXIP1 RIF1 RIF1 LIG4 LIG4 ABRAXAS1 ABRAXAS1 HERC2 HERC2 POLL POLL TDP2 TDP2 H2BC1 H2BC1 TP53BP1 TP53BP1 LOC486670 LOC486670 BARD1 BARD1 BABAM1 BABAM1 UIMC1 UIMC1 PIAS4 PIAS4 H2AX H2AX LOC482202 LOC482202 ATM ATM LOC478743 LOC478743 NSD2 NSD2 NBN NBN UBE2V2 UBE2V2 XRCC5 XRCC5 H2BC21 H2BC21 J9P0B2_CANLF J9P0B2_CANLF NHEJ1 NHEJ1 H2BC18 H2BC18 RAD50 RAD50 UBE2N-2 UBE2N-2 LOC488290 LOC488290 LOC488264 LOC488264 ENSCAFP00000046288 ENSCAFP00000046288 ENSCAFP00000046717 ENSCAFP00000046717 H2BC10 H2BC10 RNF8 RNF8 RNF168 RNF168 BABAM2 BABAM2 TDP1 TDP1 DCLRE1C DCLRE1C XRCC6 XRCC6 KAT5 KAT5 XRCC4 XRCC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MDC1Mediator of DNA damage checkpoint 1. (1912 aa)
LOC100685589DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (418 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
PAXIP1PAX interacting protein 1. (1035 aa)
RIF1Replication timing regulatory factor 1. (2549 aa)
LIG4DNA ligase. (911 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (543 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4929 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (625 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (330 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
TP53BP1Tumor protein p53 binding protein 1. (1936 aa)
LOC486670Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
BARD1BRCA1 associated RING domain 1. (737 aa)
BABAM1BRISC and BRCA1 A complex member 1. (336 aa)
UIMC1Ubiquitin interaction motif containing 1. (720 aa)
PIAS4Protein inhibitor of activated STAT 4. (521 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
LOC482202Histone H2B; Belongs to the histone H2B family. (126 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
LOC478743Histone H2B; Belongs to the histone H2B family. (126 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1344 aa)
NBNNibrin. (886 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (145 aa)
XRCC5X-ray repair cross complementing 5. (829 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
J9P0B2_CANLFHistone domain-containing protein; Belongs to the histone H2B family. (277 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (135 aa)
RAD50RAD50 double strand break repair protein. (1312 aa)
UBE2N-2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC488290Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC488264Histone H2B; Belongs to the histone H2B family. (435 aa)
ENSCAFP00000046288Histone H2B; Belongs to the histone H2B family. (177 aa)
ENSCAFP00000046717MPN domain-containing protein. (239 aa)
H2BC10Histone H2B; Belongs to the histone H2B family. (126 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (736 aa)
RNF168Ring finger protein 168. (585 aa)
BABAM2BRISC and BRCA1 A complex member 2. (388 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (639 aa)
DCLRE1CDNA cross-link repair 1C. (715 aa)
XRCC6X-ray repair cross complementing 6. (612 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (579 aa)
XRCC4X-ray repair cross complementing 4. (341 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.