STRINGSTRING
MDC1 MDC1 RMI1 RMI1 CLSPN CLSPN CCNA2 CCNA2 MRE11 MRE11 CCNA1 CCNA1 RFC3 RFC3 PPP4R2 PPP4R2 WRN WRN TOPBP1 TOPBP1 RAD17 RAD17 ATR ATR RAD9B RAD9B ABRAXAS1 ABRAXAS1 HERC2 HERC2 RFC5 RFC5 H2BC1 H2BC1 CHEK1 CHEK1 RAD9A RAD9A BLM BLM ATRIP ATRIP TP53BP1 TP53BP1 LOC486670 LOC486670 RFC4 RFC4 DNA2 DNA2 BARD1 BARD1 UBA52 UBA52 BABAM1 BABAM1 RHNO1 RHNO1 EXO1 EXO1 UIMC1 UIMC1 PPP4C PPP4C TIPIN TIPIN BRIP1 BRIP1 RBBP8 RBBP8 TOP3A TOP3A RAD1 RAD1 RMI2 RMI2 PIAS4 PIAS4 RPA1 RPA1 RPS27A RPS27A H2AX H2AX LOC482202 LOC482202 ATM ATM RNF4 RNF4 LOC478743 LOC478743 NSD2 NSD2 NBN NBN UBE2V2 UBE2V2 SIRT6 SIRT6 H2BC21 H2BC21 J9P0B2_CANLF J9P0B2_CANLF H2BC18 H2BC18 RAD50 RAD50 UBE2N-2 UBE2N-2 LOC488290 LOC488290 LOC488264 LOC488264 ENSCAFP00000046288 ENSCAFP00000046288 ENSCAFP00000046717 ENSCAFP00000046717 TIMELESS TIMELESS ENSCAFP00000050780 ENSCAFP00000050780 RFC2 RFC2 H2BC10 H2BC10 RNF8 RNF8 RNF168 RNF168 BABAM2 BABAM2 RPA3 RPA3 CDK2 CDK2 RPA2 RPA2 KAT5 KAT5 HUS1 HUS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MDC1Mediator of DNA damage checkpoint 1. (1912 aa)
RMI1RecQ mediated genome instability 1. (634 aa)
CLSPNClaspin. (1339 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
RFC3Replication factor C subunit 3. (356 aa)
PPP4R2Protein phosphatase 4 regulatory subunit 2. (416 aa)
WRNWRN RecQ like helicase. (1574 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1513 aa)
RAD17RAD17 checkpoint clamp loader component. (680 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (427 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (543 aa)
HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4929 aa)
RFC5Replication factor C subunit 5. (339 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
CHEK1Checkpoint kinase 1. (454 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa)
BLMBLM RecQ like helicase. (1420 aa)
ATRIPATR interacting protein. (792 aa)
TP53BP1Tumor protein p53 binding protein 1. (1936 aa)
LOC486670Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
RFC4Replication factor C subunit 4. (363 aa)
DNA2DNA replication helicase/nuclease 2. (1017 aa)
BARD1BRCA1 associated RING domain 1. (737 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
BABAM1BRISC and BRCA1 A complex member 1. (336 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (255 aa)
EXO1Exonuclease 1. (836 aa)
UIMC1Ubiquitin interaction motif containing 1. (720 aa)
PPP4CSerine/threonine-protein phosphatase. (307 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (286 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1243 aa)
RBBP8RB binding protein 8, endonuclease. (909 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (989 aa)
RAD1RAD1 checkpoint DNA exonuclease. (281 aa)
RMI2RecQ mediated genome instability 2. (156 aa)
PIAS4Protein inhibitor of activated STAT 4. (521 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
LOC482202Histone H2B; Belongs to the histone H2B family. (126 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
RNF4Ring finger protein 4. (190 aa)
LOC478743Histone H2B; Belongs to the histone H2B family. (126 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1344 aa)
NBNNibrin. (886 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (145 aa)
SIRT6Sirtuin 6. (403 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
J9P0B2_CANLFHistone domain-containing protein; Belongs to the histone H2B family. (277 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (135 aa)
RAD50RAD50 double strand break repair protein. (1312 aa)
UBE2N-2UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC488290Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC488264Histone H2B; Belongs to the histone H2B family. (435 aa)
ENSCAFP00000046288Histone H2B; Belongs to the histone H2B family. (177 aa)
ENSCAFP00000046717MPN domain-containing protein. (239 aa)
TIMELESSTimeless circadian regulator. (1297 aa)
ENSCAFP00000050780Ubiquitin-like domain-containing protein. (151 aa)
RFC2Replication factor C subunit 2. (367 aa)
H2BC10Histone H2B; Belongs to the histone H2B family. (126 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (736 aa)
RNF168Ring finger protein 168. (585 aa)
BABAM2BRISC and BRCA1 A complex member 2. (388 aa)
RPA3Uncharacterized protein. (351 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
RPA2Replication protein A2. (390 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (579 aa)
HUS1HUS1 checkpoint clamp component. (420 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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