(82 nodes) Regulation of TP53 Activity through Phosphorylation network (Canis lupus familiaris)

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second shell of interactors

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proteins of unknown 3D structure

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experimentally determined

Predicted Interactions

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	DYRK2	Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
	TAF11	TATA-box binding protein associated factor 11. (211 aa)
	RMI1	RecQ mediated genome instability 1. (634 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1286 aa)
	CCNA2	Cyclin A2; Belongs to the cyclin family. (432 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
	PLK3	Serine/threonine-protein kinase PLK. (768 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (545 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (597 aa)
	TAF3	TATA-box binding protein associated factor 3. (932 aa)
	SUPT16H	SPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (421 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	WRN	WRN RecQ like helicase. (1574 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1513 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
	CSNK2A1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (391 aa)
	RAD17	RAD17 checkpoint clamp loader component. (680 aa)
	ATR	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2644 aa)
	SSRP1	FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (708 aa)
	RAD9B	Cell cycle checkpoint control protein; Belongs to the rad9 family. (427 aa)
	PRKAG1	Protein kinase AMP-activated non-catalytic subunit gamma 1. (330 aa)
	HIPK1	Homeodomain interacting protein kinase 1. (1298 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (239 aa)
	RFC5	Replication factor C subunit 5. (339 aa)
	TAF5	TATA-box binding protein associated factor 5. (801 aa)
	CHEK1	Checkpoint kinase 1. (454 aa)
	RAD9A	Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa)
	TAF12	TFIID_20kDa domain-containing protein. (161 aa)
	BLM	BLM RecQ like helicase. (1420 aa)
	TAF4	TATA-box binding protein associated factor 4. (848 aa)
	ATRIP	ATR interacting protein. (792 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	DNA2	DNA replication helicase/nuclease 2. (1017 aa)
	BARD1	BRCA1 associated RING domain 1. (737 aa)
	TAF6	TATA-box binding protein associated factor 6. (678 aa)
	UBA52	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
	RHNO1	RAD9-HUS1-RAD1 interacting nuclear orphan 1. (255 aa)
	EXO1	Exonuclease 1. (836 aa)
	TAF7L	TATA-box binding protein associated factor 7 like. (504 aa)
	BRIP1	BRCA1 interacting protein C-terminal helicase 1. (1243 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	TAF4B	TATA-box binding protein associated factor 4b. (867 aa)
	RBBP8	RB binding protein 8, endonuclease. (909 aa)
	TOP3A	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (989 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	RAD1	RAD1 checkpoint DNA exonuclease. (281 aa)
	RMI2	RecQ mediated genome instability 2. (156 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (532 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	NOC2L	NOC2 like nucleolar associated transcriptional repressor. (757 aa)
	STK11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
	AK6	Uncharacterized protein. (307 aa)
	RPS27A	Ubiquitin-like domain-containing protein. (156 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	TP53RK	TP53 regulating kinase. (302 aa)
	TAF7	TATA-box binding protein associated factor 7. (349 aa)
	NBN	Nibrin. (886 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (405 aa)
	TAF1	Transcription initiation factor TFIID subunit. (1989 aa)
	TAF9B	TATA-box binding protein associated factor 9b. (289 aa)
	RAD50	RAD50 double strand break repair protein. (1312 aa)
	NUAK1	NUAK family kinase 1. (666 aa)
	TAF2	TATA-box binding protein associated factor 2. (1258 aa)
	CSNK2A2	Casein kinase 2 alpha 2. (571 aa)
	PRKAB1	Protein kinase AMP-activated non-catalytic subunit beta 1. (275 aa)
	ENSCAFP00000050780	Ubiquitin-like domain-containing protein. (151 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (573 aa)
	RFC2	Replication factor C subunit 2. (367 aa)
	AURKB	Aurora kinase B; Belongs to the protein kinase superfamily. (399 aa)
	CSNK2B	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (292 aa)
	TAF15	TATA-box binding protein associated factor 15. (579 aa)
	RPA3	Uncharacterized protein. (351 aa)
	CDK5	Cyclin dependent kinase 5. (390 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
	RPA2	Replication protein A2. (390 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (579 aa)
	TPX2	TPX2 microtubule nucleation factor. (755 aa)
	TBP	TATA-box binding protein. (324 aa)
	MDM4	MDM4 regulator of p53. (604 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...] (529 aa)
	HUS1	HUS1 checkpoint clamp component. (420 aa)

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AK6	TAF1	ENSCAFP00000030344	ENSCAFP00000038541	Uncharacterized protein.	Transcription initiation factor TFIID subunit.	0.903
AK6	TAF10	ENSCAFP00000030344	ENSCAFP00000009728	Uncharacterized protein.	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family.	0.969
AK6	TAF11	ENSCAFP00000030344	ENSCAFP00000001780	Uncharacterized protein.	TATA-box binding protein associated factor 11.	0.967
AK6	TAF12	ENSCAFP00000030344	ENSCAFP00000017254	Uncharacterized protein.	TFIID_20kDa domain-containing protein.	0.939
AK6	TAF15	ENSCAFP00000030344	ENSCAFP00000053210	Uncharacterized protein.	TATA-box binding protein associated factor 15.	0.802
AK6	TAF2	ENSCAFP00000030344	ENSCAFP00000044286	Uncharacterized protein.	TATA-box binding protein associated factor 2.	0.958
AK6	TAF3	ENSCAFP00000030344	ENSCAFP00000007470	Uncharacterized protein.	TATA-box binding protein associated factor 3.	0.922
AK6	TAF4	ENSCAFP00000030344	ENSCAFP00000018423	Uncharacterized protein.	TATA-box binding protein associated factor 4.	0.947
AK6	TAF4B	ENSCAFP00000030344	ENSCAFP00000026784	Uncharacterized protein.	TATA-box binding protein associated factor 4b.	0.932
AK6	TAF5	ENSCAFP00000030344	ENSCAFP00000015277	Uncharacterized protein.	TATA-box binding protein associated factor 5.	0.952
AK6	TAF6	ENSCAFP00000030344	ENSCAFP00000021623	Uncharacterized protein.	TATA-box binding protein associated factor 6.	0.969
AK6	TAF7	ENSCAFP00000030344	ENSCAFP00000037152	Uncharacterized protein.	TATA-box binding protein associated factor 7.	0.849
AK6	TAF7L	ENSCAFP00000030344	ENSCAFP00000025998	Uncharacterized protein.	TATA-box binding protein associated factor 7 like.	0.843
AK6	TAF9B	ENSCAFP00000030344	ENSCAFP00000039548	Uncharacterized protein.	TATA-box binding protein associated factor 9b.	0.901
AK6	TBP	ENSCAFP00000030344	ENSCAFP00000065523	Uncharacterized protein.	TATA-box binding protein.	0.932
ATM	ATR	ENSCAFP00000035996	ENSCAFP00000011639	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998
ATM	ATRIP	ENSCAFP00000035996	ENSCAFP00000018463	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR interacting protein.	0.848
ATM	BARD1	ENSCAFP00000035996	ENSCAFP00000021054	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1 associated RING domain 1.	0.888
ATM	BLM	ENSCAFP00000035996	ENSCAFP00000018251	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BLM RecQ like helicase.	0.910
ATM	BRIP1	ENSCAFP00000035996	ENSCAFP00000026175	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1 interacting protein C-terminal helicase 1.	0.852