STRINGSTRING
SKP1 SKP1 MCM3 MCM3 PSME4 PSME4 ORC3 ORC3 CUL1 CUL1 PSMB2 PSMB2 PSMD5 PSMD5 CCNA2 CCNA2 ORC5 ORC5 PSMC2 PSMC2 MCM6 MCM6 PSMC4 PSMC4 CCNA1 CCNA1 MCM4 MCM4 PSMF1 PSMF1 PSMD9 PSMD9 PSMC3 PSMC3 PSMD14 PSMD14 PSMB5 PSMB5 PSME1 PSME1 PSMA7 PSMA7 PSMD4 PSMD4 PSMD2 PSMD2 PSMB4 PSMB4 PSMC5 PSMC5 PSMA6 PSMA6 UBA52 UBA52 MCM7 MCM7 PSMB6 PSMB6 CDC6 CDC6 PSMD3 PSMD3 PSMB3 PSMB3 PSMC1 PSMC1 PSMA8 PSMA8 PSMD11 PSMD11 SKP2 SKP2 PSMA5 PSMA5 CDT1 CDT1 PSMB10 PSMB10 PSMB1 PSMB1 RPS27A RPS27A PSMD10 PSMD10 PSMD13 PSMD13 PSMD12 PSMD12 PSMB9 PSMB9 LOC100687259 LOC100687259 J9P2T7_CANLF J9P2T7_CANLF PSMD7 PSMD7 PSMA3 PSMA3 MCM2 MCM2 ORC2 ORC2 ORC1 ORC1 ENSCAFP00000047134 ENSCAFP00000047134 PSMA4 PSMA4 MCM5 MCM5 PSMC6 PSMC6 ENSCAFP00000050780 ENSCAFP00000050780 RBX1 RBX1 PSMB7 PSMB7 PSMA2 PSMA2 PSME2 PSME2 CDK2 CDK2 MCM8 MCM8 PSMD1 PSMD1 ORC4 ORC4 ORC6 ORC6 PSMA1 PSMA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (163 aa)
MCM3Minichromosome maintenance complex component 3; Belongs to the MCM family. (817 aa)
PSME4Proteasome activator subunit 4. (1762 aa)
ORC3Origin recognition complex subunit 3. (773 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD5Uncharacterized protein. (500 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (421 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
PSMF1Proteasome inhibitor subunit 1. (271 aa)
PSMD9Proteasome 26S subunit, non-ATPase 9. (223 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
PSMD14Proteasome 26S subunit, non-ATPase 14. (308 aa)
PSMB5Proteasome subunit beta. (263 aa)
PSME1Proteasome activator subunit 1. (249 aa)
PSMA7Proteasome endopeptidase complex. (178 aa)
PSMD4Proteasome 26S subunit, non-ATPase 4. (377 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
PSMB6Proteasome subunit beta. (239 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
PSMD3Proteasome 26S subunit, non-ATPase 3. (534 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
PSMA8Proteasome subunit alpha type. (250 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
CDT1Chromatin licensing and DNA replication factor 1. (769 aa)
PSMB10Proteasome subunit beta. (272 aa)
PSMB1Proteasome subunit beta. (241 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (226 aa)
PSMD13Proteasome 26S subunit, non-ATPase 13. (376 aa)
PSMD12Proteasome 26S subunit, non-ATPase 12. (456 aa)
PSMB9Proteasome subunit beta. (209 aa)
LOC100687259AAA domain-containing protein; Belongs to the AAA ATPase family. (365 aa)
J9P2T7_CANLFUncharacterized protein. (461 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (324 aa)
PSMA3Proteasome endopeptidase complex. (257 aa)
MCM2DNA helicase; Belongs to the MCM family. (933 aa)
ORC2Origin recognition complex subunit 2. (610 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (864 aa)
ENSCAFP00000047134Proteasome endopeptidase complex. (216 aa)
PSMA4Proteasome subunit alpha 4. (290 aa)
MCM5Minichromosome maintenance complex component 5; Belongs to the MCM family. (689 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (403 aa)
ENSCAFP00000050780Ubiquitin-like domain-containing protein. (151 aa)
RBX1Ring-box 1. (108 aa)
PSMB7Proteasome subunit beta. (315 aa)
PSMA2Proteasome subunit alpha type. (295 aa)
PSME2Proteasome activator subunit 2. (253 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
MCM8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (848 aa)
PSMD126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (953 aa)
ORC4Origin recognition complex subunit 4. (581 aa)
ORC6Origin recognition complex subunit 6. (395 aa)
PSMA1Proteasome subunit alpha type. (267 aa)
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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